シクロデキストリン両親媒性誘導体、これを調製する方法、およびこれの使用

Japanese Patent JP2007509218

A

Cyclodextrin derivatives with substituent groups derived from 6-24C alkylamido derivatives of amino-acids and attached to the cyclodextrin system by amide linkages, are new. New cyclodextrin derivatives comprise formula (I). [Image] R 1>-NH-E-AA-(L 1>) p(L 2>)q (II); E : 1-15C hydrocarbyl (optionally unsaturated, optionally with heteroatoms); AA : an amino-acid residue; L 1>, L 2>6-24C hydrocarbyl (linear, branched or cyclic, optionally unsaturated, optionally with heteroatoms); p, q : 0 or 1 (at least one of these must be other than 0); R 2>H, methyl, isopropyl, hydroxypropyl or a sulfobutyl ether group; R 3>H, or R 2>(except when R 2>is hydroxypropyl); all R 4>groups : OH or R 2>(not if R 2>= hydroxypropyl), or one or more R 4>is R 1>and the others are either OH or R 2>(not if R 2>is hydroxypropyl); n : 5, 6 or 7 Independent claims are also included for (1) a method for the preparation of (I) by reacting cyclodextrin derivatives of formula (VII) with compounds of formula AA-(L 1>) p(L 2>) q(VIII) (2) inclusion complexes of (I) and hydrophobic compounds; and (3) organized surface-active systems containing (I) or inclusion complexes of (2). [Image] E : as for E, but with a free functional group which reacts with OH, amino, COOH or SH groups in amino acids to form a covalent bond; AA : an amino-acid with a free OH, amino, COOH or SH group.

Perli, Bruno
Muthar, Stephanu
Pilar, Florence

JP2006536144A

April 12, 2007

October 21, 2004

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

C08B37/16; A61K47/24; A61K47/40; A61K47/48; C08B37/00

JPH0481403A

1992-03-16

WO2001083564A1	2001-11-08
WO2000066635A1	2000-11-09
ES2053399A1	1994-07-16

Michiteru Soga
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku

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