Title:
標的化用化合物
Document Type and Number:
Japanese Patent JP2007517506
Kind Code:
A
Abstract:
The invention provides a compound comprising a target specific portion and an effector portion wherein the target specific portion comprises or consists of a monoclonal antibody having specificity for oncofoetal fibronectin, or a fragment or variant thereof which retains the antigen binding specificity of the parent monoclonal antibody and the effector portion comprises or consists of interleukin-12, or a functional fragment or variant thereof, characterized in the monoclonal antibody having specificity for oncofoetal fibronectin binds to a region of oncofoetal fibronectin other than the ED-B region. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, e.g. in the treatment of cancer.
Inventors:
Stephen Gillies
Kin-Min Lo
Yang Run
Rakesh Belma
Kin-Min Lo
Yang Run
Rakesh Belma
Application Number:
JP2006546342A
Publication Date:
July 05, 2007
Filing Date:
January 05, 2005
Export Citation:
Assignee:
Md lexigen research center corporation
Antisoma PLC
Antisoma PLC
International Classes:
C12N15/09; A61K38/00; A61K39/395; A61K47/48; A61K48/00; A61P35/00; C07K14/54; C07K16/24; C07K16/30; C07K16/44; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12P21/02; C12P21/08
Other References:
JPN6010051911, Ｃａｎｃｅｒ Ｒｅｓ．， ２００３， Ｖｏｌ．６３， ｐ．３２０２−３２１０
JPN6010051912, Ｃａｎｃｅｒ Ｒｅｓ．， ２００３， Ｖｏｌ．６３， ｐ．１１４４−１１４７
JPN5006021244, ＨＡＬＩＮ Ｃ, ＮＡＴＵＲＥ ＢＩＯＴＥＣＨＮＯＬＯＧＹ, 200203, Ｖ２０ Ｎ３, Ｐ２６４−２６９, US, ＮＡＴＵＲＥ ＰＵＢＬＩＳＨＩＮＧ
JPN6010051913, Ｊ． Ｐａｔｈｏｌｏｇｙ， ２００１， Ｖｏｌ．１９３， ｐ．２５６−２６２
JPN6010051914, Ｊ． Ｃ． Ｂ．， １９８９， Ｖｏｌ．１０８， ｐ．１１３９−１１４８
JPN6010051915, Ｃａｎｃｅｒ Ｒｅｓ．， １９９９， Ｖｏｌ．５９， ｐ．３４７−３５２
JPN6010051912, Ｃａｎｃｅｒ Ｒｅｓ．， ２００３， Ｖｏｌ．６３， ｐ．１１４４−１１４７
JPN5006021244, ＨＡＬＩＮ Ｃ, ＮＡＴＵＲＥ ＢＩＯＴＥＣＨＮＯＬＯＧＹ, 200203, Ｖ２０ Ｎ３, Ｐ２６４−２６９, US, ＮＡＴＵＲＥ ＰＵＢＬＩＳＨＩＮＧ
JPN6010051913, Ｊ． Ｐａｔｈｏｌｏｇｙ， ２００１， Ｖｏｌ．１９３， ｐ．２５６−２６２
JPN6010051914, Ｊ． Ｃ． Ｂ．， １９８９， Ｖｏｌ．１０８， ｐ．１１３９−１１４８
JPN6010051915, Ｃａｎｃｅｒ Ｒｅｓ．， １９９９， Ｖｏｌ．５９， ｐ．３４７−３５２
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro