ポリエンポリケチド、その生成方法及び医薬品としての使用[関連出願]本出願は、2003年1月21日出願の米国仮出願第60/441,123号、2003年8月13日出願の米国仮出願第60/494,568号、2003年5月13日出願の米国仮出願第60/469,810号及び2003年8月1日出願の米国仮出願第60/491,516号に対する優先権を主張するものである。

Japanese Patent JP2007525148

A

This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.

Buckman Bryan Oh
Mucarpin James Bee
Zazopros Emanuel
Farnet Chris M

JP2006500436A

September 06, 2007

January 21, 2004

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Ecopia Biosciences Inc.

C12N15/09; A61K31/70; A61K31/7032; A61K31/7048; A61K31/7052; A61K35/74; A61P31/00; A61P31/10; A61P35/00; A61P35/02; C07C215/24; C07C225/14; C07C235/28; C07C237/16; C07C279/22; C07C305/14; C07H5/06; C07H15/04; C07H15/10; C07H15/18; C07H15/203; C07H15/26; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N9/00; C12P7/42; C12P11/00; C12P13/00; C12P13/02; C12P19/44; C12R1/465

JP2006528664A

2006-12-21

WO2003062458A2

2003-07-31

Masaki Hirota

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