Title:
遺伝子発現プロファイリングによる急性骨髄性白血病の分類、診断、および予後
Document Type and Number:
Japanese Patent JP2007527238
Kind Code:
A
Abstract:
The present invention relates to methods of genetic analysis for the classification, diagnosis and prognosis of acute myeloid leukemia (AML). The invention provides a method for producing a classification scheme for AML comprising the steps of a) providing a plurality of reference samples, the reference samples comprising cell samples from a plurality of reference subjects affected by AML; b) providing reference profiles by establishing a gene expression profile for each of the reference samples individually; c) clustering the individual reference profiles according to similarity; and d) assigning an AML class to each cluster. The invention further relates to a method for classifying the AML of an AML-affected subject, to a method for diagnosing AML in a subject, and to a method of determining the prognosis for an AML-affected subject.
Inventors:
Moore House Michael John
Bulk Petrus Jacobus Maria
Delwell Hendrick Rudolph
Lowenberg bob
Van der spect Petrus Johannes
Bulk Petrus Jacobus Maria
Delwell Hendrick Rudolph
Lowenberg bob
Van der spect Petrus Johannes
Application Number:
JP2007500702A
Publication Date:
September 27, 2007
Filing Date:
February 23, 2005
Export Citation:
Assignee:
Erasmus Universitate Rotterdam
International Classes:
C12Q1/68; C12M1/00; C12N15/09; C12Q1/02; G01N33/53; G01N37/00; G06F19/00; G16B25/10
Foreign References:
| EP1043676A2 | 2000-10-11 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi