アンドロゲン受容体モジュレーターとしての17-β-アセトアミド-4-アザステロイド

Title:

アンドロゲン受容体モジュレーターとしての17-β-アセトアミド-4-アザステロイド

Document Type and Number:

Japanese Patent JP2007532550

Kind Code:

A

Abstract:

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

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Inventors:

One, Chiapin
McBain, Carroll A

Application Number:

JP2007507446A

Publication Date:

November 15, 2007

Filing Date:

April 04, 2005

Export Citation:

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Assignee:

MERCK & COMPANY INCOPORATED

International Classes:

C07J73/00; A61K31/122; A61K31/352; A61K31/473; A61K31/506; A61K31/557; A61K31/565; A61K31/58; A61K31/59; A61K31/663; A61K33/06; A61K33/16; A61K38/00; A61K38/22; A61K38/23; A61K38/27; A61K38/55; A61K45/00; A61P1/02; A61P3/02; A61P3/04; A61P3/06; A61P3/14; A61P5/18; A61P5/30; A61P7/00; A61P7/06; A61P9/10; A61P11/00; A61P13/08; A61P15/10; A61P15/12; A61P17/00; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P25/24; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07D221/18; C07D401/12

Domestic Patent References:

JPH06100587A	1994-04-12
JPH07508033A	1995-09-07

Foreign References:

US5693809A	1997-12-02
WO2003092588A2	2003-11-13

Other References:

JPN6010047141, Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．, 1995, Ｖｏｌ．３８，　Ｎｏ．７, ｐ．１１５８−１１７３
JPN6010047149, Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．, 1986, Ｖｏｌ．２９，　Ｎｏ．１１, ｐ．２２９８−２３１５

Attorney, Agent or Firm:

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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