Title:
オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用
Document Type and Number:
Japanese Patent JP2007537288
Kind Code:
A
Abstract:
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
Inventors:
Scott, Terence Elle.
Raffleniel, Debra
Janno Kakis, Nick
Biscar-live, beret
Brown, Larry El.
McKen, Jennifer
Raffleniel, Debra
Janno Kakis, Nick
Biscar-live, beret
Brown, Larry El.
McKen, Jennifer
Application Number:
JP2007513370A
Publication Date:
December 20, 2007
Filing Date:
May 12, 2005
Export Citation:
Assignee:
Baxter International Inc.
Children's Hospital of Pittsburgh
Children's Hospital of Pittsburgh
International Classes:
A61K48/00; A61K9/00; A61K9/16; A61K9/50; A61K31/7088; A61P1/18; A61P3/10; C12N15/09; C12N15/11; C12N15/113
Domestic Patent References:
| JPH04283510A | 1992-10-08 | |||
| JPH0436233A | 1992-02-06 | |||
| JP2002538174A | 2002-11-12 | |||
| JP2003502283A | 2003-01-21 | |||
| JP2007537284A | 2007-12-20 |
Foreign References:
| WO1999053903A1 | 1999-10-28 | |||
| WO2000041679A1 | 2000-07-20 | |||
| WO2003083089A2 | 2003-10-09 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita