Title:
インサイチュー硬化ペースト、その製造および使用
Document Type and Number:
Japanese Patent JP2008501455
Kind Code:
A
Abstract:
An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the filed of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design.The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the paste of the invention.
Inventors:
Hella Brand Claus
Sidler Michael
Schutz Andreas
Pompe Cornelius
Friez Wolfgang
Sidler Michael
Schutz Andreas
Pompe Cornelius
Friez Wolfgang
Application Number:
JP2007526304A
Publication Date:
January 24, 2008
Filing Date:
June 09, 2005
Export Citation:
Assignee:
Sil Technology Game Behr
International Classes:
A61L27/00; A61L27/12; A61L27/34; A61L27/44; A61L27/46; A61L27/48; A61L27/50; A61L27/54; A61L27/56; A61L27/58; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/46
Domestic Patent References:
| JPH0523388A | 1993-02-02 | |||
| JPH07163654A | 1995-06-27 | |||
| JPS63153069A | 1988-06-25 | |||
| JPH08510713A | 1996-11-12 |
Foreign References:
| WO2002070029A2 | 2002-09-12 | |||
| WO2004105825A1 | 2004-12-09 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi