Title:
抗ヒトTRAIL受容体DR5モノクローナル抗体(AD5-10)およびその製法と用途
Document Type and Number:
Japanese Patent JP2008509938
Kind Code:
A
Abstract:
The present invention discloses a monoclonal antibody against the extracellular domain of human tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 (death receptor 5), The present invention also provides a method of producing the monoclonal antibody, amino acid sequences of the variable regions of the monoclonal antibody's heavy chain and light chain, as well as use of the monoclonal antibody for preparation of a medicament in the treatment of various cancers and /or AIDS.
Inventors:
Ryu Yang Shin
Guo Yarbin
Jen Dashan
Guo Yarbin
Jen Dashan
Application Number:
JP2007526167A
Publication Date:
April 03, 2008
Filing Date:
March 07, 2005
Export Citation:
Assignee:
THE INSTITUTE OF BASIC MEDICAL SCIENCES OF CHINESE ACADEMY OF MEDICAL SCIENCES
International Classes:
C07K16/28; A61K39/395; A61P31/18; A61P35/00; A61P43/00; C07K16/30; C12N5/10; C12N5/18; C12N15/02; C12N15/09; C12P21/08
Foreign References:
| WO2003037913A2 | 2003-05-08 |
Attorney, Agent or Firm:
Kunio Miura
Daisuke Ando
Daisuke Ando