Title:
細菌の鉄取り込み部位
Document Type and Number:
Japanese Patent JP2008510793
Kind Code:
A
Abstract:
Pharmaceutical compositions comprising inhibitors of the SirABC or FhuC iron-siderophore transport system, and their use for treating an infection of Staphylococcus aureus in a subject Screening methods for mdentifymg SirABC or FhuC iron-siderophore transport system inhibitors are also disclosed
Inventors:
Heinrich, David, E.
Dale, Suzanne
Dale, Suzanne
Application Number:
JP2007529045A
Publication Date:
April 10, 2008
Filing Date:
August 26, 2005
Export Citation:
Assignee:
THE UNIVERSITY OF WESTERN ONTARIO
International Classes:
A61K38/00; A61K31/7088; A61K45/00; A61K48/00; A61P31/04; C12Q1/14; C12N15/09
Other References:
JPN7011001448; Ｈｅｉｎｒｉｃｈｓ， Ｊ．Ｈ． ｅｔ ａｌ．: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ＳｉｒＡ， ａｎ ｉｒｏｎ-ｒｅｇｕｌａｔｅｄ ｐｒｏｔｅｉｎ ｆｒｏｍ Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ．' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８１（５）, 1999, ｐ．１４３６-４３
JPN7011001449; 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ａ ｍｅｍｂｒａｎｅ ｐｅｒｍｅａｓｅ ｉｎｖｏｌｖｅｄ ｉｎ ｉｒｏｎ-ｈｙｄｒｏｘａｍａｔｅ ｔｒａｎｓｐｏｒｔ ｉｎ' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２（１６）, 2000, ｐ．４３９４-４００
JPN7011001448; Ｈｅｉｎｒｉｃｈｓ， Ｊ．Ｈ． ｅｔ ａｌ．: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ＳｉｒＡ， ａｎ ｉｒｏｎ-ｒｅｇｕｌａｔｅｄ ｐｒｏｔｅｉｎ ｆｒｏｍ Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ．' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８１（５）, 1999, ｐ．１４３６-４３
JPN7011001449; 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ａ ｍｅｍｂｒａｎｅ ｐｅｒｍｅａｓｅ ｉｎｖｏｌｖｅｄ ｉｎ ｉｒｏｎ-ｈｙｄｒｏｘａｍａｔｅ ｔｒａｎｓｐｏｒｔ ｉｎ' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２（１６）, 2000, ｐ．４３９４-４００
JPN7011001449; 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ａ ｍｅｍｂｒａｎｅ ｐｅｒｍｅａｓｅ ｉｎｖｏｌｖｅｄ ｉｎ ｉｒｏｎ-ｈｙｄｒｏｘａｍａｔｅ ｔｒａｎｓｐｏｒｔ ｉｎ' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２（１６）, 2000, ｐ．４３９４-４００
JPN7011001448; Ｈｅｉｎｒｉｃｈｓ， Ｊ．Ｈ． ｅｔ ａｌ．: 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ＳｉｒＡ， ａｎ ｉｒｏｎ-ｒｅｇｕｌａｔｅｄ ｐｒｏｔｅｉｎ ｆｒｏｍ Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ．' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８１（５）, 1999, ｐ．１４３６-４３
JPN7011001449; 'Ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ａ ｍｅｍｂｒａｎｅ ｐｅｒｍｅａｓｅ ｉｎｖｏｌｖｅｄ ｉｎ ｉｒｏｎ-ｈｙｄｒｏｘａｍａｔｅ ｔｒａｎｓｐｏｒｔ ｉｎ' Ｊ．Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２（１６）, 2000, ｐ．４３９４-４００
Attorney, Agent or Firm:
Mizuno Yuuki
Junji Endo
Junji Endo