Title:
マイクロ流体制御による区画化されたスクリーニング
Document Type and Number:
Japanese Patent JP2008516251
Kind Code:
A
Abstract:
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
Inventors:
Andrew Griffith
David Waits
Darren Link
Ann Kung Ho
Jerome Vivet
David Waits
Darren Link
Ann Kung Ho
Jerome Vivet
Application Number:
JP2007536255A
Publication Date:
May 15, 2008
Filing Date:
October 12, 2005
Export Citation:
Assignee:
Medical Research Council
President and Fellows of Harvard College
President and Fellows of Harvard College
International Classes:
G01N35/08; B01F5/02; B01F5/06; B01F13/00; B01L3/00; C12Q1/68; G01N33/53; G01N33/543; G01N33/555; G01N37/00; B01F3/08; C40B50/08; G01N15/14
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita