Title:
NK3受容体で活性を有する化合物およびその医薬における使用
Document Type and Number:
Japanese Patent JP2008519800
Kind Code:
A
Abstract:
The invention also relates to compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R1 is phenyl or cyclohexyl, either of which is optionally substituted by 1, 2 or 3 halogen atoms, which atoms may be the same or different; R2 is C1-6alkyl or C3-6cycloalkyl; n is 1 or 2; R3 is hydrogen, C1-6alkyl or C3-6cycloalkyl; X is -(C=O)- or -SO2-; R4 is C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6haloalkoxy, amino, monoC1-6alkylamino or diC1-6alkylamino, or R4 is heterocyclyl or carbocyclyl, either of which is optionally substituted independently by one or more halogen, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy or C1-6haloalkoxy; R5 is phenyl or thienyl, either of which is optionally substituted by 1, 2 or 3 halogen atoms; and y is 0, 1 or 2; wherein when y is 1 or 2, Y is a halogen atom, and wherein when y is 2 the halogen atoms may be the same or different. Also disclosed are use of the compounds in treating diseases and conditions mediated by activation of the NK3 receptor, compositions containing the derivatives and processes for their preparation.
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Inventors:
Daniel Marcus Bradley
Roderick Alan Porter
Paul William Smith
Rachel Elizabeth Ann Stead
Antonio Quoc Keon Bonn
Roderick Alan Porter
Paul William Smith
Rachel Elizabeth Ann Stead
Antonio Quoc Keon Bonn
Application Number:
JP2007540606A
Publication Date:
June 12, 2008
Filing Date:
November 10, 2005
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D215/52; A61K31/47; A61K31/4709; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07D405/12; C07D409/04
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita