Title:
CCR2Bアンタゴニストとしてのヘテロ環式化合物
Document Type and Number:
Japanese Patent JP2008525397
Kind Code:
A
Abstract:
Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.
Inventors:
Justin Fairfield Bower
Jeffrey Philip Poiser
Paul Turner
David Waterson
John Winter
Jeffrey Philip Poiser
Paul Turner
David Waterson
John Winter
Application Number:
JP2007547621A
Publication Date:
July 17, 2008
Filing Date:
December 19, 2005
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D211/26; A61K31/495; A61K31/496; A61K31/5377; A61K31/551; A61P1/04; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/10; A61P27/10; A61P29/00; A61P31/18; A61P35/00; A61P37/08; A61P43/00; C07D211/56; C07D241/04; C07D265/30; C07D295/20; C07D401/04; C07D401/06; C07D401/08; C07D405/04; C07D405/06; C07D409/04; C07D409/06; C07D409/12; C07D409/14; C07D413/04; C07D413/06; C07D413/12; C07D417/06; C07D417/08; C07D417/12
Domestic Patent References:
| JPH04273821A | 1992-09-30 | |||
| JPH03206071A | 1991-09-09 | |||
| JPS6289679A | 1987-04-24 | |||
| JP2004508354A | 2004-03-18 | |||
| JP2001526178A | 2001-12-18 | |||
| JP2008505872A | 2008-02-28 | |||
| JP2003530393A | 2003-10-14 | |||
| JPH04273821A | 1992-09-30 | |||
| JPH03206071A | 1991-09-09 | |||
| JPS6289679A | 1987-04-24 | |||
| JP2004508354A | 2004-03-18 | |||
| JP2001526178A | 2001-12-18 | |||
| JP2008505872A | 2008-02-28 | |||
| JP2003530393A | 2003-10-14 |
Foreign References:
| WO2004041777A2 | 2004-05-21 | |||
| WO2002079151A1 | 2002-10-10 | |||
| WO2004002531A1 | 2004-01-08 | |||
| WO2000035877A1 | 2000-06-22 | |||
| WO2006016039A1 | 2006-02-16 | |||
| WO2005082854A1 | 2005-09-09 | |||
| US3133061A | 1964-05-12 | |||
| US3541085A | 1970-11-17 | |||
| WO2004002531A1 | 2004-01-08 | |||
| WO2000035877A1 | 2000-06-22 | |||
| WO2006016039A1 | 2006-02-16 | |||
| WO2005082854A1 | 2005-09-09 | |||
| US3133061A | 1964-05-12 | |||
| US3541085A | 1970-11-17 | |||
| WO2004041777A2 | 2004-05-21 | |||
| WO2002079151A1 | 2002-10-10 |
Other References:
JPN6011050175; Ｄｅａｎ Ａ． Ｗａｃｋｅｒ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２, 2002, ｐ．１７８５-１７８９
JPN6011050174; Ｂｒｏｏｋｅｓ Ｐ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ , 1957, ｐ．３１６５-３１７２
JPN6011050174; Ｂｒｏｏｋｅｓ Ｐ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ , 1957, ｐ．３１６５-３１７２
JPN6011050175; Ｄｅａｎ Ａ． Ｗａｃｋｅｒ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２, 2002, ｐ．１７８５-１７８９
JPN6011050174; Ｂｒｏｏｋｅｓ Ｐ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ , 1957, ｐ．３１６５-３１７２
JPN6011050174; Ｂｒｏｏｋｅｓ Ｐ． ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ , 1957, ｐ．３１６５-３１７２
JPN6011050175; Ｄｅａｎ Ａ． Ｗａｃｋｅｒ ｅｔ ａｌ．: Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．１２, 2002, ｐ．１７８５-１７８９
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki