Title:
抗糖尿病化合物の新規な結晶形態
Document Type and Number:
Japanese Patent JP2008533033
Kind Code:
A
Abstract:
Novel crystalline forms of two indole compounds connected to phenoxyalkylcarboxylic acid groups are selective PPAR gamma partial agonists that are useful in the treatment of type 2 diabetes, hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. The novel crystal forms include a crystalline free acid dihydrate and crystalline free acid anhydrate of one compound and several crystalline forms of the free acid and the sodium salt of the second compound. The invention also relates to pharmaceutical compositions comprising these novel crystal forms, processes to prepare the crystal forms and their pharmaceutical compositions, and uses of the crystal forms in the treatment of type 2 diabetes and other PPAR gamma modulated diseases.
Inventors:
Chiao, Thalien
Marcou, Jean-Francois
Boardman, David
Reyes, Achilles A
Marcou, Jean-Francois
Boardman, David
Reyes, Achilles A
Application Number:
JP2008500934A
Publication Date:
August 21, 2008
Filing Date:
March 10, 2006
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D209/12; A61K31/404; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura