Title:
アンギオテンシン変換酵素阻害剤の有機酸化窒素増強塩、組成物および使用法
Document Type and Number:
Japanese Patent JP2008533171
Kind Code:
A
Abstract:
The invention describes compositions and kits comprising at least qrie organic nitric oxide enhancing salt of an angiotensin converting enzyme inhibitor, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; Q) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating ophthalmic disorders; (o) treating metabolic syndrome; and (p) treating hyperlipidemia. The organic nitric oxide enhancing compounds that form salts with the angiotensin converting enzyme inhibitors are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.
Inventors:
Garvey David S.
Application Number:
JP2008502091A
Publication Date:
August 21, 2008
Filing Date:
March 17, 2006
Export Citation:
Assignee:
Nitromed Incorporated
International Classes:
A61K45/00; A61K31/131; A61K31/401; A61K31/404; A61K31/44; A61K31/445; A61K31/55; A61K31/675; A61K38/55; A61P1/16; A61P3/00; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P19/10; A61P27/02; A61P39/06
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi