Title:
ラセミ体アルキル-5-ハロペンタ-4-エンカルボン酸または-カルボン酸エステルの調製方法
Document Type and Number:
Japanese Patent JP2009502821
Kind Code:
A
Abstract:
A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-4-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and R2 is a C1-C4-alkyl radical, in the presence of a metal alkoxide of the formula MOR3, in which M may be Na, K or Li, and R3 is a C1-C4-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C1-C6 alcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function.
Inventors:
Royal leaf. peter
Steinbower, Gerhard
Burger, christian
Steinbower, Gerhard
Burger, christian
Application Number:
JP2008523159A
Publication Date:
January 29, 2009
Filing Date:
July 03, 2006
Export Citation:
Assignee:
DSM Fine Chemicals Austria NFG GM Bhauer und Zeokerge
International Classes:
C07C51/09; C07C51/44; C07C51/48; C07C57/52; C07C67/343; C07C69/65
Domestic Patent References:
| JPS5616442A | 1981-02-17 | |||
| JPH08245508A | 1996-09-24 | |||
| JP2003506345A | 2003-02-18 |
Foreign References:
| WO2004052828A1 | 2004-06-24 |
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Ikeda adult
Masakazu Noda
Yoshinori Shimizu
Ikeda adult