Title:
外部シゲラタンパク質F(OSPF)の治療的な使用
Document Type and Number:
Japanese Patent JP2009509938
Kind Code:
A
Abstract:
The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
Inventors:
Alviv, Lawrence
Sansonette, Philip
Parso, Claude
Don Uk, Kim
Hualipong, Almere
Sansonette, Philip
Parso, Claude
Don Uk, Kim
Hualipong, Almere
Application Number:
JP2008530543A
Publication Date:
March 12, 2009
Filing Date:
September 15, 2006
Export Citation:
Assignee:
Unstated Paste Pasture
International Classes:
A61K45/00; A61K38/00; A61K39/112; A61P31/04; A61P35/00; A61P37/06; C12N1/21; C12N15/09; C12Q1/02; C12Q1/42; A61K38/46
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura