Title:
アラビノース修飾ヌクレオチドを含む低分子干渉リボ核酸二重鎖
Document Type and Number:
Japanese Patent JP2009513112
Kind Code:
A
Abstract:
Small interfering ribonucleic acid duplexes that inhibit gene expression containing at least one arabinose modified nucleotide are provided. Preferably, the duplexes contain ribonucleotides at least one arabinose modified nucleotide is 2'-deoxy-2'-fluoroarabinonucleotide (FANA) nucleotide.
Inventors:
Dam hamasad
Ferrari Nikolai
Ferrari Nikolai
Application Number:
JP2008536894A
Publication Date:
April 02, 2009
Filing Date:
October 26, 2006
Export Citation:
Assignee:
Topigen Pharmaceuticals Incorporated
International Classes:
C12N15/09; A61K31/7105; A61K31/713; A61K48/00; A61P31/14; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki