Title:
縮合環トロンビンレセプターアンタゴニスト
Document Type and Number:
Japanese Patent JP2009533450
Kind Code:
A
Abstract:
Fused-ring, heterocyclic-substituted tricyclics of the formula (I) or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein (II) represents an optional double bond, and wherein An, E n , M n , G n , J n , R 3 , n 7 , R 8 , R 9 , R 10 , R 11 , R 32 , R 33 , X, Y, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
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Inventors:
Xia, Yang
Sheria, Mariappan Buoy.
Chakkala Manil, Samuel
Sheria, Mariappan Buoy.
Chakkala Manil, Samuel
Application Number:
JP2009505466A
Publication Date:
September 17, 2009
Filing Date:
April 11, 2007
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D498/04; A61K31/4439; A61K45/00; A61P1/00; A61P1/16; A61P3/10; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/10; A61P13/12; A61P15/10; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/06; A61P25/28; A61P27/06; A61P29/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita