Title:
椎間円板の修復と再生、および、関節修復と再生のための基盤の作成
Document Type and Number:
Japanese Patent JP2010508126
Kind Code:
A
Abstract:
Methods for the engineering and preparation of intervertebral disc repair scaffolds and articulating joint repair scaffolds are disclosed. The methodology utilizes either magnetic resonance images or combined magnetic resonance and computed tomography images as a template for creating either the intervertebral scaffold or the joint repair scaffold (e.g., osteochondral scaffold) with fixation to the underlying bone. The disc scaffold design may include an outer annulus that may contain desired structures and a central nucleus pulposus region that could either contain a designed microstructure or a contained hydrogel. The osteochondral scaffold may include a bone compartment interface with a cartilage compartment. The bone compartment may interface with a cutout portion of the bone through fixation components. Different microstructure designs may be created for the bone and cartilage compartment to represent desired mechanical and mass transport properties. The microstructure controls elastic and permeability property distribution within the scaffold.
Inventors:
Phosphorus, cheer-in
Lamarca, Frank
Feinberg, Stephen, E.
Murphy, William, Elle.
Aidox, James, Earl.
Hollister, Scott, Jay.
Lamarca, Frank
Feinberg, Stephen, E.
Murphy, William, Elle.
Aidox, James, Earl.
Hollister, Scott, Jay.
Application Number:
JP2009535421A
Publication Date:
March 18, 2010
Filing Date:
October 30, 2007
Export Citation:
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
WISCONSIN ALUMNI RESEARCH FOUNDATION
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
A61F2/44; A61L27/00
Domestic Patent References:
| JP2001500409A | 2001-01-16 | |||
| JP2006510452A | 2006-03-30 | |||
| JP2001500409A | 2001-01-16 | |||
| JP2006510452A | 2006-03-30 |
Foreign References:
| US5609635A | 1997-03-11 | |||
| US20050112397A1 | 2005-05-26 | |||
| US20030069718A1 | 2003-04-10 | |||
| US20030069718A1 | 2003-04-10 |
Other References:
JPN7012003891; 'Ｂｉｏ-ＣＡＤ ｍｏｄｅｌｉｎｇ ａｎｄ ｉｔｓ ａｐｐｌｉｃａｔｉｏｎｓ ｉｎ ｃｏｍｐｕｔｅｒ-ａｉｄｅｄ ｔｉｓｓｕｅ ｅｎｇｉｎｅｅｒｉｎｇ' ｃｏｍｐｕｔｅｒ-ａｉｄｅｄ ｄｅｓｉｇｎ ３７, 20050202, １０９７-１１１４
Attorney, Agent or Firm:
Takao Kawasaki
Kazumasa Kumagai
Kazumasa Kumagai