Title:
2,5-ビス-(2,2,2-トリフルオロエトキシ)-N-(2-ピペリジルメチル)-ベンズアミド及びその塩類の調製方法
Document Type and Number:
Japanese Patent JP2010508331
Kind Code:
A
Abstract:
A process for the preparation of Flecainide acetate, its salts, in particular its pharmaceutically acceptable salts, and intermediates thereof is described wherein 2,5-dibromotoluene is used as a starting material. The method involves a technique for preparing the starting material 2,5- bis (2,2,2-trifluroethoxy)toluene in high yields by reacting 2,5-dibromotoluene with 2,2,2-trifluoroethanol in the presence of a base and a copper-containing catalyst.
Inventors:
Dicane, dyna
Yaunbergs, Janice
Yaunbergs, Janice
Application Number:
JP2009535082A
Publication Date:
March 18, 2010
Filing Date:
November 02, 2007
Export Citation:
Assignee:
GRINDEKS,a joint stock company
International Classes:
C07D211/26; B01J27/055; C07B61/00
Attorney, Agent or Firm:
Keiichi Ota