Title:
覚醒を促進するためのIhチャネル阻害剤
Document Type and Number:
Japanese Patent JP2010513227
Kind Code:
A
Abstract:
The present invention relates to the use of an I h channel inhibitor for the manufacture of a medicament for the promotion of wakefulness in a subject in need thereof, in particular, wherein the subject is suffering from excessive sleepiness which may result from a sleep disorder.
Inventors:
Ward, Nicholas Mathew
Rift, Heraldus Stefanus Franciscus
Marston, Hiyu
Rift, Heraldus Stefanus Franciscus
Marston, Hiyu
Application Number:
JP2009533794A
Publication Date:
April 30, 2010
Filing Date:
October 18, 2007
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
A61K31/42; A61K31/4168; A61K31/55; A61P25/20; A61P43/00
Other References:
JPN5009014967; ＲＡＭＥＳＨ ＶＩＪＡＹ: ＰＨＹＳＩＯＬＯＧＹ ＡＮＤ ＢＥＨＡＶＩＯＲ Ｖ５７ Ｎ１, 1994, Ｐ１７１-１７５
JPN5009014968; ＤＥ ＳＡＩＮＴ ＨＩＬＡＩＲＥ Ｚ: ＢＥＨＡＶＩＯＵＲＡＬ ＮＥＵＲＯＬＯＧＹ Ｖ１０ Ｎ２-３, 1997, Ｐ９３-１００
JPN5009014969; ＧＡＩＬＬＡＲＤ Ｊ-Ｍ: ＮＥＵＲＯＰＳＹＣＨＯＢＩＯＬＯＧＹ Ｖ１３ Ｎ１-２, 1985, Ｐ２３-２５
JPN7013000282; ＤＡＬＬＥ，Ｃ． ｅｔ ａｌ: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｔｈｅ Ｉｈ ｃｕｒｒｅｎｔ ｉｎ ｉｓｏｌａｔｅｄ ｐｅｒｉｐｈｅｒａｌ ｎｅｒｖｅ： Ａ ｎｏｖｅｌ ｍｏｄｅ ｏｆ ｐｅｒｉｐｈｅｒａｌ ａｎｔｉｎｏｃｉｃｅｐｔｉｏ' Ｍｕｓｃｌｅ ＆ Ｎｅｒｖｅ Ｖｏｌ．２４， Ｎｏ．２, 2001, ｐ．２５４-２６１
JPN5009014968; ＤＥ ＳＡＩＮＴ ＨＩＬＡＩＲＥ Ｚ: ＢＥＨＡＶＩＯＵＲＡＬ ＮＥＵＲＯＬＯＧＹ Ｖ１０ Ｎ２-３, 1997, Ｐ９３-１００
JPN5009014969; ＧＡＩＬＬＡＲＤ Ｊ-Ｍ: ＮＥＵＲＯＰＳＹＣＨＯＢＩＯＬＯＧＹ Ｖ１３ Ｎ１-２, 1985, Ｐ２３-２５
JPN7013000282; ＤＡＬＬＥ，Ｃ． ｅｔ ａｌ: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｔｈｅ Ｉｈ ｃｕｒｒｅｎｔ ｉｎ ｉｓｏｌａｔｅｄ ｐｅｒｉｐｈｅｒａｌ ｎｅｒｖｅ： Ａ ｎｏｖｅｌ ｍｏｄｅ ｏｆ ｐｅｒｉｐｈｅｒａｌ ａｎｔｉｎｏｃｉｃｅｐｔｉｏ' Ｍｕｓｃｌｅ ＆ Ｎｅｒｖｅ Ｖｏｌ．２４， Ｎｏ．２, 2001, ｐ．２５４-２６１
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura