Title:
軽減された肝毒性を含む最小限に抑制された副作用を有するアセトアミノフェン組成物
Document Type and Number:
Japanese Patent JP2010513229
Kind Code:
A
Abstract:
Solid tablets or gel capsules comprising acetaminophen and an agent that promotes glutathione production that mitigates adverse hepatic effects of acetaminophen. The glutathione production promoter is preferably n-acetylcysteine or other mercapto-2-amino alkyl carboxylic acid having glutathione production promoting properties. A preferred composition comprises acetaminophen (200 mg to 750 mg) and N-acetylcysteine (200 mg to 600 mg). Alternatively and/or in addition to N-acetylcysteine the composition can contain at least one of methionine and cysteine. Preferred compositions can contain at least one of an opiate (or synthetic equivalent), an antihistamine, an antiemetic, and a sedative. Physical encapsulation of the ingredients optionally with or in place of a fragrance is used to make the composition more acceptable to patients by mitigating noxious properties of the glutathione production promoter. Preferably, the compositions are prepared for patient self administration in tablet or gel capsule form wherein the patients can take the medication without the need for close oversight of a medical caregiver.
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Inventors:
SODERLING,Eric M.
Application Number:
JP2009540327A
Publication Date:
April 30, 2010
Filing Date:
December 08, 2007
Export Citation:
Assignee:
SODERLING,Eric M.
International Classes:
A61K31/167; A61K9/48; A61K31/198; A61K45/00; A61P1/16
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Atsushi Honda
Miho Ikegami
Makoto Onda
Atsushi Honda
Miho Ikegami