Title:
ブプレノルフィンとナルトレキソンを含む改良医薬組成物
Document Type and Number:
Japanese Patent JP2010520183
Kind Code:
A
Abstract:
An analgesic composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naltrexone such that the ratio by weight of buprenorphine to naltrexone delivered to or reaching the plasma of a patient is in the range 100:1 to 5000:1. The analgesic action of the buprenorphine is potentiated by the low dose of naltrexone. Also provided are a method of treatment of pain and the use of buprenorphine and naltrexone for the manufacture of a medicament.
Inventors:
Chapleo Christopher Bourne
Hyde Neil
Hyde Neil
Application Number:
JP2009551253A
Publication Date:
June 10, 2010
Filing Date:
February 15, 2008
Export Citation:
Assignee:
Lekit Benquicer Healthcare (UK) Limited
International Classes:
A61K31/485; A61K9/08; A61P25/04; A61P29/00; C07D489/02
Domestic Patent References:
| JP2001526229A | 2001-12-18 | |||
| JP2003514013A | 2003-04-15 | |||
| JP2001526229A | 2001-12-18 |
Foreign References:
| US5272149A | 1993-12-21 | |||
| EP0319243A1 | 1989-06-07 | |||
| US20050191340A1 | 2005-09-01 | |||
| US5272149A | 1993-12-21 | |||
| EP0319243A1 | 1989-06-07 |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Shunichiro Mashiba
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Shunichiro Mashiba