Title:
物質の結晶化を追跡する方法と対応する微小流体装置およびスクリーニング方法
Document Type and Number:
Japanese Patent JP2010520475
Kind Code:
A
Abstract:
The crystallization of chemical species/polymorphs comprises forming droplets of a solution of a substance with optionally different concentrations of said substance in an inert phase; producing and storing the droplets in at least one storage microchannel (1); forming crystals in all droplets; increasing the temperature in order to induce the dissolution of at least a portion of the crystals in at least some droplets; and analyzing the crystallization and dissolution process.
Inventors:
Matthew Juanico
Philip Laval
Jack Leng
Jean-Baptiste Salmon
Philip Laval
Jack Leng
Jean-Baptiste Salmon
Application Number:
JP2009552246A
Publication Date:
June 10, 2010
Filing Date:
March 05, 2008
Export Citation:
Assignee:
RHODIA OPERATIONS
International Classes:
G01N1/28; G01N21/65; G01N25/14; G01N35/00; G01N35/08; G01N37/00
Domestic Patent References:
| JP2006513986A | 2006-04-27 | |||
| JP2002541455A | 2002-12-03 | |||
| JPH04182398A | 1992-06-29 |
Foreign References:
| WO2005037424A1 | 2005-04-28 | |||
| WO2006101851A2 | 2006-09-28 |
Other References:
JPN6012033586; Ｂｉｌｌｙ Ｔ． Ｃ． Ｌａｕ ｅｔ ａｌ．: 'Ａ Ｃｏｍｐｌｅｔｅ Ｍｉｃｒｏｆｌｕｉｄｉｃ Ｓｃｒｅｅｎｉｎｇ Ｐｌａｔｆｏｒｍ ｆｏｒ Ｒａｔｉｏｎａｌ Ｐｒｏｔｅｉｎ Ｃｒｙｓｔａｌｌｉｚａｔｉｏｎ' Ｊ． ＡＭ． ＣＨＥＭ． ＳＯＣ． Ｖｏｌ． １２９, 20061223, ｐｐ． ４５４-４５５
JPN6012002805; Ｗｅｎ-Ｃｈｉ Ｃｈａｏ ｅｔ ａｌ．: 'Ｃｏｎｔｒｏｌ ｏｆ Ｃｏｎｃｅｎｔｒａｔｉｏｎ ａｎｄ Ｖｏｌｕｍｅ Ｇｒａｄｉｅｎｔｓ ｉｎ Ｍｉｃｒｏｆｌｕｉｄｉｃ Ｄｒｏｐｌｅｔ Ａｒｒａｙｓ ｆｏｒ Ｐｒｏｔｅｉｎ Ｃｒｙｓｔａｌｌｉｚ' Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ ２６ｔｈ Ａｎｎｕａｌ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｃｏｎｆｅｒｅｎｃｅ ｏｆ ｔｈｅ ＩＥＥＥ ＥＭＢＳ , 200409, ｐｐ． ２６２３-２６２６
JPN6012057270; Ｃａｒｌ Ｌ． Ｈａｎｓｅｎ ｅｔ ａｌ．: 'Ａ Ｍｉｃｒｏｆｌｕｉｄｉｃ Ｄｅｖｉｃｅ ｆｏｒ Ｋｉｎｅｔｉｃ Ｏｐｔｉｍｉｚａｔｉｏｎ ｏｆ Ｐｒｏｔｅｉｎ Ｃｒｙｓｔａｌｌｉｚａｔｉｏｎ ａｎｄ Ｉｎ Ｓｉｔｕ Ｓｔｒｕｃｔｕｒｅ Ｄｅｔｅ' Ｊ． ＡＭ． ＣＨＥＭ． ＳＯＣ． Ｖｏｌ． １２８, 20060215, ｐｐ． ３１４２-３１４３
JPN7012004472; Ｍｅｇａｎ Ｊ． Ａｎｄｅｒｓｏｎ ｅｔ ａｌ．: 'Ｐｈａｓｅ ｋｎｏｗｌｅｄｇｅ ｅｎａｂｌｅｓ ｒａｔｉｏｎａｌ ｓｃｒｅｅｎｓ ｆｏｒ ｐｒｏｔｅｉｎ ｃｒｙｓｔａｌｌｉｚａｔｉｏｎ' ＰＮＡＳ Ｖｏｌ． １０３， Ｎｏ． ４５, 20061107, ｐｐ． １６７４６-１６７５１
JPN7012004473; Ｃａｒｌ Ｌ． Ｈａｎｓｅｎ ｅｔ ａｌ．: 'Ｓｙｓｔｅｍａｔｉｃ ｉｎｖｅｓｔｉｇａｔｉｏｎ ｏｆ ｐｒｏｔｅｉｎ ｐｈａｓｅ ｂｅｈａｖｉｏｒ ｗｉｔｈ ａ ｍｉｃｒｏｆｌｕｉｄｉｃ ｆｏｒｍｕｌａｔｏｒ' ＰＮＡＳ Ｖｏｌ． １０１， Ｎｏ． ４０, 20041005, ｐｐ． １４４３１．１４４３６
JPN7012004475; Ｊｅａｎ-Ｂａｐｔｉｓｔｅ Ｓａｌｍｏｎ ｅｔ ａｌ．: 'Ｉｎ ｓｉｔｕ Ｒａｍａｎ ｉｍａｇｉｎｇ ｏｆ ｉｎｔｅｒｄｉｆｆｕｓｉｏｎ ｉｎ ａ ｍｉｃｒｏｃｈａｎｎｅｌ' ＡＰＰＬＩＥＤ ＰＨＹＳＩＣＳ ＬＥＴＴＥＲＳ Ｖｏｌ． ８６， Ｎｏ． ０９４１０６, 2005, ｐｐ． １-３
JPN6012002805; Ｗｅｎ-Ｃｈｉ Ｃｈａｏ ｅｔ ａｌ．: 'Ｃｏｎｔｒｏｌ ｏｆ Ｃｏｎｃｅｎｔｒａｔｉｏｎ ａｎｄ Ｖｏｌｕｍｅ Ｇｒａｄｉｅｎｔｓ ｉｎ Ｍｉｃｒｏｆｌｕｉｄｉｃ Ｄｒｏｐｌｅｔ Ａｒｒａｙｓ ｆｏｒ Ｐｒｏｔｅｉｎ Ｃｒｙｓｔａｌｌｉｚ' Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ ２６ｔｈ Ａｎｎｕａｌ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｃｏｎｆｅｒｅｎｃｅ ｏｆ ｔｈｅ ＩＥＥＥ ＥＭＢＳ , 200409, ｐｐ． ２６２３-２６２６
JPN6012057270; Ｃａｒｌ Ｌ． Ｈａｎｓｅｎ ｅｔ ａｌ．: 'Ａ Ｍｉｃｒｏｆｌｕｉｄｉｃ Ｄｅｖｉｃｅ ｆｏｒ Ｋｉｎｅｔｉｃ Ｏｐｔｉｍｉｚａｔｉｏｎ ｏｆ Ｐｒｏｔｅｉｎ Ｃｒｙｓｔａｌｌｉｚａｔｉｏｎ ａｎｄ Ｉｎ Ｓｉｔｕ Ｓｔｒｕｃｔｕｒｅ Ｄｅｔｅ' Ｊ． ＡＭ． ＣＨＥＭ． ＳＯＣ． Ｖｏｌ． １２８, 20060215, ｐｐ． ３１４２-３１４３
JPN7012004472; Ｍｅｇａｎ Ｊ． Ａｎｄｅｒｓｏｎ ｅｔ ａｌ．: 'Ｐｈａｓｅ ｋｎｏｗｌｅｄｇｅ ｅｎａｂｌｅｓ ｒａｔｉｏｎａｌ ｓｃｒｅｅｎｓ ｆｏｒ ｐｒｏｔｅｉｎ ｃｒｙｓｔａｌｌｉｚａｔｉｏｎ' ＰＮＡＳ Ｖｏｌ． １０３， Ｎｏ． ４５, 20061107, ｐｐ． １６７４６-１６７５１
JPN7012004473; Ｃａｒｌ Ｌ． Ｈａｎｓｅｎ ｅｔ ａｌ．: 'Ｓｙｓｔｅｍａｔｉｃ ｉｎｖｅｓｔｉｇａｔｉｏｎ ｏｆ ｐｒｏｔｅｉｎ ｐｈａｓｅ ｂｅｈａｖｉｏｒ ｗｉｔｈ ａ ｍｉｃｒｏｆｌｕｉｄｉｃ ｆｏｒｍｕｌａｔｏｒ' ＰＮＡＳ Ｖｏｌ． １０１， Ｎｏ． ４０, 20041005, ｐｐ． １４４３１．１４４３６
JPN7012004475; Ｊｅａｎ-Ｂａｐｔｉｓｔｅ Ｓａｌｍｏｎ ｅｔ ａｌ．: 'Ｉｎ ｓｉｔｕ Ｒａｍａｎ ｉｍａｇｉｎｇ ｏｆ ｉｎｔｅｒｄｉｆｆｕｓｉｏｎ ｉｎ ａ ｍｉｃｒｏｃｈａｎｎｅｌ' ＡＰＰＬＩＥＤ ＰＨＹＳＩＣＳ ＬＥＴＴＥＲＳ Ｖｏｌ． ８６， Ｎｏ． ０９４１０６, 2005, ｐｐ． １-３
Attorney, Agent or Firm:
Axis International Patent Business Corporation