Title:
PET/MRフロー推定を用いて補われる自動診断及び自動整列
Document Type and Number:
Japanese Patent JP2010520478
Kind Code:
A
Abstract:
A scanner (10) is used to provide images for automated diagnoses of neurodegenerative diseases, such as Alzheimers disease. The images are registered (90) to a template (78). The aligned image is analyzed (60) in relation to reference image data (76, 80) which has been registered to the template which is contained in a knowledge maintenance engine (70) for similar patterns of hypo-intensity that would indicate (in the case of an FDG tracer) reduced glucose uptake in the brain. The most appropriate reference images for the analysis of the present study are chosen by a filter (74). The present study is then given a dementia score (84) as a diagnostic feature vector that indicates to a clinician the type and severity of the ailment based on the analysis. The scanner (10) can produce PET or other metabolic and MR images for diagnosis. The MR can be used to measure blood flow rate into the brain. From the blood flow rate and the metabolic image, tracer, e.g. FDG, uptake maps can be generated for use in the automated diagnoses.
Inventors:
Young Stuart M
Coon michael
Wenzel Fabian
Carlsen Invercy
Mates Kirsten
Buchert Ralph
Coon michael
Wenzel Fabian
Carlsen Invercy
Mates Kirsten
Buchert Ralph
Application Number:
JP2009552302A
Publication Date:
June 10, 2010
Filing Date:
February 14, 2008
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
G01T1/161; A61B5/055; G01T1/20
Domestic Patent References:
| JP2006320387A | 2006-11-30 | |||
| JP2006167289A | 2006-06-29 | |||
| JP2006208250A | 2006-08-10 | |||
| JP2007527743A | 2007-10-04 | |||
| JPH07204170A | 1995-08-08 | |||
| JP2006320387A | 2006-11-30 |
Foreign References:
| WO2005081168A2 | 2005-09-01 | |||
| WO2005117707A2 | 2005-12-15 | |||
| WO2006009752A1 | 2006-01-26 | |||
| WO2005081168A2 | 2005-09-01 | |||
| WO2005117707A2 | 2005-12-15 |
Other References:
JPN5010005338; Ｈ． Ｍａｔｓｕｄａ， Ｓ． Ｍｉｚｕｍｕｒａ， Ｔ． Ｓｏｍａ， Ｎ． Ｔａｋｅｍｕｒａ: 'Ｃｏｎｖｅｒｓｉｏｎ ｏｆ ｂｒａｉｎ ＳＰＥＣＴ ｉｍａｇｅｓ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｃｏｌｌｉｍａｔｏｒｓ ａｎｄ ｒｅｃｏｎｓｔｒｕｃｔｉｏｎ ｐｒｏｃｅｓｓｅｓ ｆｏｒ ａｎａｌ' Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．２５， Ｎｏ．１, 200401, ｐ．６７-７４, Ｂｒｉｔｉｓｈ Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｓｏｃｉｅｔｙ
JPN5010005337; Ｋ． Ｉｓｈｉｉ， Ａ．Ｋ． Ｋｏｎｏ， Ｈ． Ｓａｓａｋｉ， Ｎ． Ｍｉｙａｍｏｔｏ， Ｔ． Ｆｕｋｕｄａ， Ｓ． Ｓａｋａｍｏｔｏ， Ｅ． Ｍｏｒｉ: 'Ｆｕｌｌｙ ａｕｔｏｍａｔｉｃ ｄｉａｇｎｏｓｔｉｃ ｓｙｓｔｅｍ ｆｏｒ ｅａｒｌｙ- ａｎｄ ｌａｔｅ-ｏｎｓｅｔ ｍｉｌｄ Ａｌｚｈｅｉｍｅｒ'ｓ ｄｉｓｅａｓｅ ｕｓｉｎｇ ＦＤＧ ＰＥＴ' Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ ａｎｄ Ｍｏｌｅｃｕｌａｒ Ｉｍａｇｉｎｇ Ｖｏｌ．３３， Ｎｏ．５, 20060210, ｐ．５７
JPN6012038933; Ｃ．Ｓ． Ｐａｔｌａｋ， Ｒ．Ｇ． Ｂｌａｓｂｅｒｇ， Ｊ．Ｄ． Ｆｅｎｓｔｅｒｍａｃｈｅｒ: 'Ｇｒａｐｈｉｃａｌ Ｅｖａｌｕａｔｉｏｎ ｏｆ Ｂｌｏｏｄ-ｔｏ-Ｂｒａｉｎ Ｔｒａｎｓｆｅｒ Ｃｏｎｓｔａｎｔｓ ｆｒｏｍ Ｍｕｌｔｉｐｌｅ-Ｔｉｍｅ Ｕｐｔａｋｅ Ｄａｔａ' Ｊｏｕｒｎａｌ ｏｆ Ｃｅｒｅｂｒａｌ Ｂｌｏｏｄ Ｆｌｏｗ ＆ Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．３， Ｎｏ．１, 1983, ｐ．１-７, Ｎａｔｕｒｅ Ｐｕｂｌｉｓｈｉｎｇ Ｇｒｏｕｐ
JPN5010005338; Ｈ． Ｍａｔｓｕｄａ， Ｓ． Ｍｉｚｕｍｕｒａ， Ｔ． Ｓｏｍａ， Ｎ． Ｔａｋｅｍｕｒａ: 'Ｃｏｎｖｅｒｓｉｏｎ ｏｆ ｂｒａｉｎ ＳＰＥＣＴ ｉｍａｇｅｓ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｃｏｌｌｉｍａｔｏｒｓ ａｎｄ ｒｅｃｏｎｓｔｒｕｃｔｉｏｎ ｐｒｏｃｅｓｓｅｓ ｆｏｒ ａｎａｌ' Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．２５， Ｎｏ．１, 200401, ｐ．６７-７４, Ｂｒｉｔｉｓｈ Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｓｏｃｉｅｔｙ
JPN5010005337; Ｋ． Ｉｓｈｉｉ， Ａ．Ｋ． Ｋｏｎｏ， Ｈ． Ｓａｓａｋｉ， Ｎ． Ｍｉｙａｍｏｔｏ， Ｔ． Ｆｕｋｕｄａ， Ｓ． Ｓａｋａｍｏｔｏ， Ｅ． Ｍｏｒｉ: 'Ｆｕｌｌｙ ａｕｔｏｍａｔｉｃ ｄｉａｇｎｏｓｔｉｃ ｓｙｓｔｅｍ ｆｏｒ ｅａｒｌｙ- ａｎｄ ｌａｔｅ-ｏｎｓｅｔ ｍｉｌｄ Ａｌｚｈｅｉｍｅｒ'ｓ ｄｉｓｅａｓｅ ｕｓｉｎｇ ＦＤＧ ＰＥＴ' Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ ａｎｄ Ｍｏｌｅｃｕｌａｒ Ｉｍａｇｉｎｇ Ｖｏｌ．３３， Ｎｏ．５, 20060210, ｐ．５７
JPN6012038933; Ｃ．Ｓ． Ｐａｔｌａｋ， Ｒ．Ｇ． Ｂｌａｓｂｅｒｇ， Ｊ．Ｄ． Ｆｅｎｓｔｅｒｍａｃｈｅｒ: 'Ｇｒａｐｈｉｃａｌ Ｅｖａｌｕａｔｉｏｎ ｏｆ Ｂｌｏｏｄ-ｔｏ-Ｂｒａｉｎ Ｔｒａｎｓｆｅｒ Ｃｏｎｓｔａｎｔｓ ｆｒｏｍ Ｍｕｌｔｉｐｌｅ-Ｔｉｍｅ Ｕｐｔａｋｅ Ｄａｔａ' Ｊｏｕｒｎａｌ ｏｆ Ｃｅｒｅｂｒａｌ Ｂｌｏｏｄ Ｆｌｏｗ ＆ Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．３， Ｎｏ．１, 1983, ｐ．１-７, Ｎａｔｕｒｅ Ｐｕｂｌｉｓｈｉｎｇ Ｇｒｏｕｐ
JPN5010005338; Ｈ． Ｍａｔｓｕｄａ， Ｓ． Ｍｉｚｕｍｕｒａ， Ｔ． Ｓｏｍａ， Ｎ． Ｔａｋｅｍｕｒａ: 'Ｃｏｎｖｅｒｓｉｏｎ ｏｆ ｂｒａｉｎ ＳＰＥＣＴ ｉｍａｇｅｓ ｂｅｔｗｅｅｎ ｄｉｆｆｅｒｅｎｔ ｃｏｌｌｉｍａｔｏｒｓ ａｎｄ ｒｅｃｏｎｓｔｒｕｃｔｉｏｎ ｐｒｏｃｅｓｓｅｓ ｆｏｒ ａｎａｌ' Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ Ｖｏｌ．２５， Ｎｏ．１, 200401, ｐ．６７-７４, Ｂｒｉｔｉｓｈ Ｎｕｃｌｅａｒ Ｍｅｄｉｃｉｎｅ Ｓｏｃｉｅｔｙ
Attorney, Agent or Firm:
Susumu Tsugaru
Fueda Shusen
Takahiro Igarashi
Fueda Shusen
Takahiro Igarashi