Title:
アポトーシスを誘導するイミダゾール誘導体とその治療的用途
Document Type and Number:
Japanese Patent JP2010521421
Kind Code:
A
Abstract:
The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
Inventors:
In-Jae Shin
Mun-Lul Lee
Darren Williams
Mun-Lul Lee
Darren Williams
Application Number:
JP2009550782A
Publication Date:
June 24, 2010
Filing Date:
February 26, 2007
Export Citation:
Assignee:
Industry-Academic Corporation Foundation, Yonsei University
International Classes:
C07D233/61; A61K31/4164; A61P35/00; A61P37/00; A61P43/00; C07D233/64; C12N5/078; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| JPH107660A | 1998-01-13 |
Foreign References:
| EP0812829A1 | 1997-12-17 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro