Title:
ALK阻害剤として有用なイミダゾ[1,2-a]ピリジン誘導体
Document Type and Number:
Japanese Patent JP2011500623
Kind Code:
A
Abstract:
Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.
Inventors:
Duncan Show
Catherine Leblanc
Dimitrios Rhizos
Kathy Ritchie
Vicky Farminger
Sarah Lewis
Benoit Ornsperge
Nicolaus Johannes Steefle
Sven Weiler
Catherine Leblanc
Dimitrios Rhizos
Kathy Ritchie
Vicky Farminger
Sarah Lewis
Benoit Ornsperge
Nicolaus Johannes Steefle
Sven Weiler
Application Number:
JP2010529359A
Publication Date:
January 06, 2011
Filing Date:
October 15, 2008
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D471/04; A61K31/444; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61P1/04; A61P1/16; A61P3/10; A61P7/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P17/02; A61P17/18; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/14; A61P31/20; A61P35/00; C07B61/00
Domestic Patent References:
| JP2005537291A | 2005-12-08 | |||
| JP2005530745A | 2005-10-13 | |||
| JP2004529141A | 2004-09-24 | |||
| JP2005539000A | 2005-12-22 | |||
| JP2005518369A | 2005-06-23 | |||
| JP2003514907A | 2003-04-22 | |||
| JP2005537291A | 2005-12-08 | |||
| JP2005530745A | 2005-10-13 | |||
| JP2004529141A | 2004-09-24 | |||
| JP2005539000A | 2005-12-22 |
Foreign References:
| WO2006044509A2 | 2006-04-27 | |||
| WO2006025567A1 | 2006-03-09 | |||
| EP1382603A1 | 2004-01-21 | |||
| WO2006091671A1 | 2006-08-31 | |||
| WO2008078091A1 | 2008-07-03 | |||
| WO2006044509A2 | 2006-04-27 | |||
| WO2006025567A1 | 2006-03-09 | |||
| EP1382603A1 | 2004-01-21 |
Other References:
JPN7013002838; ＳＹＮＬＥＴＴ （１９）, 2006, ｐｐ．３２３７-３２４２
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Michiko Matsutani
Nishino Mitsuru
Sakurai Yoko
Masayuki Nakagawa
Satoshi Hashimoto
Yasushi Ochiai
Mizuhara Masahiro
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Michiko Matsutani
Nishino Mitsuru
Sakurai Yoko
Masayuki Nakagawa
Satoshi Hashimoto
Yasushi Ochiai
Mizuhara Masahiro