Title:
アミノ酸誘導体の立体選択的製造方法
Document Type and Number:
Japanese Patent JP2011503226
Kind Code:
A
Abstract:
The invention relates to a process for the stereoselective preparation of amino acid derivatives, comprising a hydrogenation reaction of the compound of formula (III), alternatively its enantiomer, wherein R is (C 1 -C 8 )-alkyl; followed by a hydrolysis reaction to obtain L-mesityl alanine, alternatively its enantiomer D-mesityl alanine and, optionally, subjecting said compound to an amino group protection reaction, particularly as Fmoc. It also comprises Fmoc-L- or Fmoc-D- mesityl alanine as products per se, useful as intermediates in preparing peptides or peptide analogs with therapeutic or biological activity.
Inventors:
Lafecas, Honey, Lawrence
Riera Escale, Antoni
Ramon Albarate, Rosario
Alonso Haruma, Monica
Riera Escale, Antoni
Ramon Albarate, Rosario
Alonso Haruma, Monica
Application Number:
JP2010534508A
Publication Date:
January 27, 2011
Filing Date:
November 19, 2008
Export Citation:
Assignee:
Bethene Peptides S.a.
International Classes:
C07C227/18; A61K38/00; C07C67/31; C07C69/675; C07C227/32; C07C229/36; C07C247/12; C07B61/00
Domestic Patent References:
| JPS36667B1 | ||||
| JPS36667B1 | ||||
| JP2007008887A | 2007-01-18 |
Other References:
JPN6013030428; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｋｏｒｅａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｖｏｌ．２６，Ｎｏ．２, 2005, ｐ．２２３-２２４
JPN6013030428; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｋｏｒｅａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｖｏｌ．２６，Ｎｏ．２, 2005, ｐ．２２３-２２４
JPN6013030430; Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．８３, 2000, ｐ．９７２-９８８
JPN6013030431; ペプチド合成の基礎と実験 第２刷, 1987, ｐ．３１-３２, 丸善株式会社
JPN6013030428; Ｂｕｌｌｅｔｉｎ ｏｆ ｔｈｅ Ｋｏｒｅａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ｖｏｌ．２６，Ｎｏ．２, 2005, ｐ．２２３-２２４
JPN6013030430; Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．８３, 2000, ｐ．９７２-９８８
JPN6013030431; ペプチド合成の基礎と実験 第２刷, 1987, ｐ．３１-３２, 丸善株式会社
Attorney, Agent or Firm:
Shohei Oguri
Hironori Honda
Toshimitsu Ichikawa
Hironori Honda
Toshimitsu Ichikawa