Title:
ヒト体液中の微小胞を測定し、特徴付けるための新規な方法
Document Type and Number:
Japanese Patent JP2011510309
Kind Code:
A
Abstract:
This disclosure provides a method to capture, detect, characterize and quantify human exosomes in small volumes of human body fluids by using a sandwich ELISA test. This method allows a full characterization of an exosome preparation, thus providing a tool to distinguish a disease-related condition from a healthy state, by the use of a non-invasive assay. In fact, this method may be useful in screening, diagnosis and prognosis of tumors, with a simple plasma sample. At the same time measurement of circulating exosomes may provide information on the level of tumor mass present in a patient. The method provided here is suitable to evaluate presence of some infectious and/or transmissible agents, such as viral proteins or prion proteins, within circulating exosomes.
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Inventors:
Stefano Faith
Mariantonia Roguzzi
Mariantonia Roguzzi
Application Number:
JP2010543379A
Publication Date:
March 31, 2011
Filing Date:
January 26, 2009
Export Citation:
Assignee:
Hansabiomedo Osauching
International Classes:
G01N33/53; G01N33/569; G01N33/574; G01N33/576
Domestic Patent References:
| JPS63118656A | 1988-05-23 | |||
| JP2005237234A | 2005-09-08 | |||
| JP2003531864A | 2003-10-28 | |||
| JP2006509185A | 2006-03-16 | |||
| JP2002530348A | 2002-09-17 | |||
| JP2003514523A | 2003-04-22 | |||
| JPS63118656A | 1988-05-23 | |||
| JP2005237234A | 2005-09-08 | |||
| JP2003531864A | 2003-10-28 | |||
| JP2006509185A | 2006-03-16 | |||
| JP2002530348A | 2002-09-17 | |||
| JP2003514523A | 2003-04-22 |
Foreign References:
| WO2007095729A1 | 2007-08-30 | |||
| WO2007127464A2 | 2007-11-08 | |||
| WO2007095729A1 | 2007-08-30 | |||
| WO2007127464A2 | 2007-11-08 |
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JPN6012059335; Ｊ Ａｌｌｅｒｇｙ Ｃｌｉｎ Ｉｍｍｕｎｏｌ． Ｖｏｌ．１２０， Ｎｏ．６, 2007, ｐ１４１８-１４２４
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Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai