Title:
遺伝子発現の転写後抑制を相乗的に生じさせることができる方法および組成物
Document Type and Number:
Japanese Patent JP2011510647
Kind Code:
A
Abstract:
The invention relates to compositions for the post-transcriptional inhibition of gene expression by means of the combined use of a modified U1 snRNA targeted at a pre-selected region in a target pre-mRNA and of a gene expression-silencing agent of the siRNA, shRNA and/or miRNA type, as well as the use of said combinations for the treatment of diseases caused by the unwanted over-expression of a protein.
Inventors:
Avalleletu, Xavier
Fortes Alonso, Maria Prificacion
Fortes Alonso, Maria Prificacion
Application Number:
JP2010544739A
Publication Date:
April 07, 2011
Filing Date:
January 29, 2009
Export Citation:
Assignee:
PROYECTO DE BIOMEDICINA CIMA, S.L.
International Classes:
A01K67/027; C12N15/113; A61K31/713; A61K48/00; A61P25/00; A61P31/00; A61P31/14; A61P31/18; A61P31/20; A61P35/00; C12N5/10; C12N15/09
Foreign References:
| EP1384784A1 | 2004-01-28 | |||
| WO2008093141A1 | 2008-08-07 |
Other References:
JPN5011005346; ＬＩＵ， Ｐ．， ｅｔ ａｌ．: 'ＭＯＤＩＦＩＥＤ Ｕ１ ｓｎＲＮＡ ＳＵＰＰＲＥＳＳＥＳ ＥＸＰＲＥＳＳＩＯＮ ＯＦ Ａ ＴＡＲＧＥＴＥＤ ＥＮＤＯＧＥＮＯＵＳ ＲＮＡ ＢＹ ＩＮＨＩＢＩＴＩＮＧ ＰＯＬＹＡＤＥＮＹＬＡＴＩＯＮ Ｏ' ＮＵＣＬＥＩＣ ＡＣＩＤＳ ＲＥＳＥＡＲＣＨ ３２（４）, 20040101, ｐｐ．１５１２-１５１７, ＯＸＦＯＲＤ ＵＮＩＶＥＲＳＩＴＹ ＰＲＥＳＳ
JPN5011005347; ＳＡＪＩＣ， Ｒ．， ｅｔ ａｌ．: 'ＵＳＥ ＯＦ ＭＯＤＩＦＩＥＤ Ｕ１ ＳＮＲＮＡＳ ＴＯ ＩＮＨＩＢＩＴ ＨＩＶ-１ ＲＥＰＬＩＣＡＴＩＯＮ' ＮＵＣＬＥＩＣ ＡＣＩＤＳ ＲＥＳＥＡＲＣＨ ３５（１）, 2007, ｐｐ．２４７-２５５
JPN5011005348; ＢＥＣＫＬＥＹ， Ｓ．Ａ．， ｅｔ ａｌ．: 'ＲＥＤＵＣＴＩＯＮ ＯＦ ＴＡＲＧＥＴ ＧＥＮＥ ＥＸＰＲＥＳＳＩＯＮ ＢＹ Ａ ＭＯＤＩＦＩＥＤ Ｕ１ ＳＮＲＮＡ' ＭＯＬＥＣＵＬＡＲ ＡＮＤ ＣＥＬＬＵＬＡＲ ＢＩＯＬＯＧＹ ２１（８）, 200104, ｐｐ．２８１５-２８２５, ＡＭＥＲＩＣＡＮ ＳＯＣＩＥＴＹ ＦＯＲ ＭＩＣＲＯＢＩＯＬＯＧＹ
JPN5011005347; ＳＡＪＩＣ， Ｒ．， ｅｔ ａｌ．: 'ＵＳＥ ＯＦ ＭＯＤＩＦＩＥＤ Ｕ１ ＳＮＲＮＡＳ ＴＯ ＩＮＨＩＢＩＴ ＨＩＶ-１ ＲＥＰＬＩＣＡＴＩＯＮ' ＮＵＣＬＥＩＣ ＡＣＩＤＳ ＲＥＳＥＡＲＣＨ ３５（１）, 2007, ｐｐ．２４７-２５５
JPN5011005348; ＢＥＣＫＬＥＹ， Ｓ．Ａ．， ｅｔ ａｌ．: 'ＲＥＤＵＣＴＩＯＮ ＯＦ ＴＡＲＧＥＴ ＧＥＮＥ ＥＸＰＲＥＳＳＩＯＮ ＢＹ Ａ ＭＯＤＩＦＩＥＤ Ｕ１ ＳＮＲＮＡ' ＭＯＬＥＣＵＬＡＲ ＡＮＤ ＣＥＬＬＵＬＡＲ ＢＩＯＬＯＧＹ ２１（８）, 200104, ｐｐ．２８１５-２８２５, ＡＭＥＲＩＣＡＮ ＳＯＣＩＥＴＹ ＦＯＲ ＭＩＣＲＯＢＩＯＬＯＧＹ
Attorney, Agent or Firm:
Konno Akio