Title:
活性薬剤分子を含有する合成小胞に結合する抗体
Document Type and Number:
Japanese Patent JP2011518185
Kind Code:
A
Abstract:
A process is provided of delivering at least one active agent cargo molecule into an neuronal cell whereby a cargo molecule is placed within a synthetic vesicle such as a liposome and a biotinylated protein such as an antibody is bound to the synthetic vesicle to form a protein bound synthetic vesicle whereby the protein recognizes a receptor expressed on the surface of a neuronal cell, and exposing the protein bound synthetic vesicle to the cell until the cargo molecule is delivered into the neuronal cell. Numerous cargo molecules are delivered by the inventive synthetic vesicle including a calpain inhibitor and a caspase inhibitor. The protein illustratively targets a cellular receptor for a ligand such as glutamate, glycine, dopamine, nicotine, muscarine, acetylcholine, or serotonin, and the like.
Inventors:
Jonathan One
Jared V. Goodman
Stephen Frank Learner
Kevin Ka-One One
Jared V. Goodman
Stephen Frank Learner
Kevin Ka-One One
Application Number:
JP2011505235A
Publication Date:
June 23, 2011
Filing Date:
April 17, 2009
Export Citation:
Assignee:
Banyan Biomarkers Incorporated
International Classes:
A61K9/127; A61K39/395; A61K45/00; A61K47/42; A61P25/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2008503590A | 2008-02-07 | |||
| JP2005521645A | 2005-07-21 | |||
| JP2005265737A | 2005-09-29 | |||
| JP2004248666A | 2004-09-09 |
Foreign References:
| US20060016705A1 | 2006-01-26 | |||
| US20070092558A1 | 2007-04-26 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro