Title:
炎症応答に対する抑制活性を有する、ホスファチジルーミオーイノシトールマンノシドの合成類似体
Document Type and Number:
Japanese Patent JP2011520946
Kind Code:
A
Abstract:
The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the prevention or treatment of a disease associated with the overexpression of cytokines or of chemokines, in particular of TNF and/or of IL-12. The invention also relates to a pharmaceutical composition comprising at least one synthetic derivative of PIM.
Inventors:
Kesen Riffel, Valery
Martin, Olivier
Front, Sophie
Martin, Olivier
Front, Sophie
Application Number:
JP2011510020A
Publication Date:
July 21, 2011
Filing Date:
May 20, 2009
Export Citation:
Assignee:
Center National de la Réchelche Scientific (Se En L S)
Universite d'Orleans
Universite d'Orleans
International Classes:
C07F9/10; A61K31/7034; A61K31/706; A61P1/16; A61P3/10; A61P9/10; A61P19/02; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00
Attorney, Agent or Firm:
Tadahiko Ito
Shinsuke Onuki
Tadashige Ito
Shinsuke Onuki
Tadashige Ito