Title:
BMPアンタゴニスト感受性が低下した骨形成タンパク質2(BMP2)変異体
Document Type and Number:
Japanese Patent JP2012520066
Kind Code:
A
Abstract:
The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
Inventors:
Zeeman, Petra
Mundoros, Stephan
Reisner, Kirsten
Duda, Georg
Zimmer, Yulia
Mundoros, Stephan
Reisner, Kirsten
Duda, Georg
Zimmer, Yulia
Application Number:
JP2011553455A
Publication Date:
September 06, 2012
Filing Date:
March 11, 2010
Export Citation:
Assignee:
Biotech Rabbit Game Bha
International Classes:
C12N15/09; A01K67/027; A61K38/00; A61K48/00; A61P1/02; A61P1/16; A61P13/12; A61P19/00; A61P25/00; A61P25/16; C07K14/51; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2011507903A | 2011-03-10 | |||
| JPH06298800A | 1994-10-25 | |||
| JP2011507903A | 2011-03-10 |
Foreign References:
| WO2001092298A2 | 2001-12-06 | |||
| WO2001092298A2 | 2001-12-06 |
Other References:
JPN6014032444; Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．１３, 2000, ３３１４-３３２４
JPN6014032444; Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．１３, 2000, ３３１４-３３２４
JPN6014032444; Ｔｈｅ ＥＭＢＯ Ｊｏｕｒｎａｌ Ｖｏｌ．１９， Ｎｏ．１３, 2000, ３３１４-３３２４
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga