がん予後診断アッセイ

Japanese Patent JP2013519082

A

The invention provides a method of prognosis of a subject with an infection, identifying a subject at greater risk of death from an infection and/or identifying a subject at greater risk of developing an infection, the method comprising detecting an amount of free light chains (FLC) in a sample from the subject, wherein a higher amount of FLC is associated with decreased survival due to the infection and/or increased risk from an infection and/or having an increased risk of developing an infection. A method of monitoring an infection, comprising detecting an amount of free light chains (FLC) in a sample from a patient having an infection and comparing the amount of FLC in the sample with an amount of FLC detected in a sample previously obtained from the patient, wherein an increase in the amount FLC detected, compared to the previous sample, indicates an increase in the infection in the patient, and a decrease in the amount of FLC indicates a decrease in the infection in the patient. Assay kits for use in the method are also provided. Assay kits comprising one or more anti-FLC antibodies and one or more anti-bacterial antigen antibodies are also provided.

Bradwell, Arthur
Mead, Graham

JP2012551687A

May 23, 2013

February 04, 2011

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The Binding Site Group Limited

G01N33/574; G01N33/53; G01N33/543

JP2008519854A	2008-06-12
JP2005249592A	2005-09-15
JP2008528995A	2008-07-31

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JPN5013003124; ＭＡＲＳＨＡＬＬ　Ｇ: 'ＢＯＲＤＥＲＬＩＮＥ　ＨＩＧＨ　ＳＥＲＵＭ　ＦＲＥＥ　ＬＩＧＨＴ　ＣＨＡＩＮ　［ＫＡＰＰＡ］／［ＬＡＭＢＤＡ］　ＲＡＴＩＯＳ　ＡＲＥ　ＳＥＥＮ　ＮＯＴ　ＯＮＬＹ　以下備考' ＡＭＥＲＩＣＡＮ　ＪＯＵＲＮＡＬ　ＯＦ　ＣＬＩＮＩＣＡＬ　ＰＡＴＨＯＬＯＧＹ Ｖ１３２　Ｎ２, 200908, Ｐ３０９, ＡＭＥＲＩＣＡＮ　ＳＯＣＩＥＴＹ　ＯＦ　ＣＬＩＮＩＣＡＬ　ＰＡＴＨＯＬＯＧＹ

Yoshiyuki Kawaguchi
Shinichi Sanuki
Takeshi Niwa

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