Title:
PI3Kにより誘発される癌のためのバイオマーカー
Document Type and Number:
Japanese Patent JP2013523807
Kind Code:
A
Abstract:
Disclosed is the discovery that the mTORC2 complex plays a role in the regulation of PKN3 phosphorylation at the turn motif threonine; and the use of the phosphorylation status of the turn motif threonine of PKN3 as a biomarker. In some embodiments, the phosphorylation status of the turn motif threonine of PKN3 is determined using an antibody that specifically binds to the turn motif threonine of a PKN3 protein, such as an anti-phosphoT860 antibody. In some embodiments, the invention relates to methods for screening compounds that have cancer therapeutic potential, methods for diagnosing cancer, methods for determining the prognosis of a patient suffering from cancer, methods for stratifying patients in a clinical trial, methods for treating a patient suffering from cancer, and methods for determining the effectiveness of a particular treatment regimen.
Inventors:
Anki Klippel-Guise
Kejivan Ansal-Kakumaz
Kejivan Ansal-Kakumaz
Application Number:
JP2013503202A
Publication Date:
June 17, 2013
Filing Date:
April 01, 2011
Export Citation:
Assignee:
Weiss LRC
International Classes:
A61K45/00; A61K39/395; A61P35/00; A61P43/00; G01N33/53
Attorney, Agent or Firm:
Noh four
High Hoji Koji
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
High Hoji Koji
Junko Miyazawa
Maki Sato
Tatsuta Miyuki