Title:
ノロウイルスに由来する免疫原性組成物および方法
Document Type and Number:
Japanese Patent JP2013533745
Kind Code:
A
Abstract:
The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
Inventors:
Setter Bar, Ethan
Medina-Selby, Angelica
Koito, Doris
Dormitzer, Philip
Medina-Selby, Angelica
Koito, Doris
Dormitzer, Philip
Application Number:
JP2013518791A
Publication Date:
August 29, 2013
Filing Date:
July 05, 2011
Export Citation:
Assignee:
Novartis Age
International Classes:
C12N15/09; C07K14/08; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12P21/02; A61K35/76; A61K39/12; A61P31/14
Domestic Patent References:
| JP2009516529A | 2009-04-23 |
Foreign References:
| WO2009039229A2 | 2009-03-26 | |||
| WO2010017542A1 | 2010-02-11 |
Other References:
JPN6015027395; ＴＡＮ， Ｍｉｎｇ ｅｔ ａｌ．: '"Ｔｈｅ Ｐ ｄｏｍａｉｎ ｏｆ ｎｏｒｏｖｉｒｕｓ ｃａｐｓｉｄ ｐｒｏｔｅｉｎ ｆｏｒｍｓ ｄｉｍｅｒ ａｎｄ ｂｉｎｄｓ ｔｏ ｈｉｓｔｏ-ｂｌｏｏｄ ｇｒｏｕｐ ａｎｔｉｇｅｎ ｒｅｃｅｐｔｏ' Ｊ． Ｖｉｒｏｌ． Ｖｏｌ． ７８, 2004, ｐ． ６２３３-６２４２
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita