Title:
ナノ粒子デリバリーシステム、その製造および使用
Document Type and Number:
Japanese Patent JP2014510040
Kind Code:
A
Abstract:
The invention pertains to thermosensitive liposomes encapsulating nanoparticles. In certain embodiments, the thermosensitive liposomes of the invention disrupt when heated at gel-to-liquid crystalline phase transition temperature (Tm) or above Tm, wherein the liposome comprises a thermosensitive lipidic membrane encapsulating nanoparticles. The nanoparticles used in the invention comprise an inorganic core the largest dimension of which is less than about 100 nm that is fully coated with an agent responsible for the presence of an electrostatic charge below −20 mV or above +20 mV at the surface of the nanoparticle, the electrostatic charge being determined by zeta potential measurements in an aqueous medium between pH 6 and 8, for a concentration of nanoparticles in suspension in the aqueous medium varying between 0.2 and 8 g/L. The invention also relates to pharmaceutical and diagnostic compositions comprising the thermosensitive liposomes as well as to their uses.
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Inventors:
Agnes Potier
Laurent Levy
Marie-Edith Mail
Matthew Germain
Laurent Levy
Marie-Edith Mail
Matthew Germain
Application Number:
JP2013550905A
Publication Date:
April 24, 2014
Filing Date:
January 31, 2012
Export Citation:
Assignee:
NANOBIOTIX
International Classes:
A61K9/127; A61K33/26; A61K47/24; A61K47/28; A61K47/34; A61K49/00; A61P35/00; A61P35/02; B82Y5/00; B82Y40/00
Domestic Patent References:
| JPH08500700A | 1996-01-23 |
Foreign References:
| US20090004258A1 | 2009-01-01 |
Other References:
J. BIOMED. NANOTECHNOL., vol. 4, no. 3, JPN6015034924, 2008, pages 313 - 318
RADIOLOGY, vol. 239, no. 2, JPN6015034926, 2006, pages 415 - 424
EUR. RADIOL., vol. Vol.20, JPN6016029130, 2010, pages 640 - 648
万有生命科学振興国際交流財団創薬工学シンポジウム, vol. Vol.5th, JPN6016029131, 2005, pages 29 - 33
東亞合成グループ研究年報, vol. 第１４号, JPN6016029134, 1 January 2011 (2011-01-01), pages 27 - 30
DATABASE EMBASE ON STN, vol. AN 0018572655, JPN6016029136, 2010
J. MAGN. MAGN. MATER., vol. Vol.285, JPN6016029138, 2004, pages 65 - 70
RADIOLOGY, vol. 239, no. 2, JPN6015034926, 2006, pages 415 - 424
EUR. RADIOL., vol. Vol.20, JPN6016029130, 2010, pages 640 - 648
万有生命科学振興国際交流財団創薬工学シンポジウム, vol. Vol.5th, JPN6016029131, 2005, pages 29 - 33
東亞合成グループ研究年報, vol. 第１４号, JPN6016029134, 1 January 2011 (2011-01-01), pages 27 - 30
DATABASE EMBASE ON STN, vol. AN 0018572655, JPN6016029136, 2010
J. MAGN. MAGN. MATER., vol. Vol.285, JPN6016029138, 2004, pages 65 - 70
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama