有機化合物 - INTRA-CELLULAR THERAPIES, INC.

Title:

有機化合物

Document Type and Number:

Japanese Patent JP2014517078

Kind Code:

A

Abstract:

The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment function block the activity of certain acetylcholine receptors and subtypes therein, and are useful treating diseases and conditions mediated by nicotinic receptor stimulation, e.g., small cell lung cancer.

Inventors:

Pong Li
Youi Pong
John Tomesh
Lawrence Pee Wenogle
Jean chiang

Application Number:

JP2014517231A

Publication Date:

July 17, 2014

Filing Date:

June 22, 2012

Export Citation:

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Assignee:

INTRA-CELLULAR THERAPIES, INC.

International Classes:

C07D401/12; A61K31/454; A61K31/4745; A61K31/7068; A61K33/243; A61K39/395; A61P11/00; A61P25/00; A61P25/28; A61P25/34; A61P31/18; A61P35/00; A61P35/04; A61P39/02; A61P43/00

Domestic Patent References:

JP2011514906A	2011-05-12
JP2004526788A	2004-09-02
JP2006525355A	2006-11-09
JP2011514906A	2011-05-12
JP2004526788A	2004-09-02

Foreign References:

US20100179186A1	2010-07-15
WO2005000821A1	2005-01-06
WO2003037274A2	2003-05-08
US20100179186A1	2010-07-15

Other References:

JPN7016000327; Ｒ．　Ｈ．　Ｈｅｎｃｈｍａｎ　ｅｔ　ａｌ: 'Ｌｉｇａｎｄ-ｉｎｄｕｃｅｄ　ｃｏｎｆｏｒｍａｔｉｏｎａｌ　ｃｈａｎｇｅ　ｉｎ　ｔｈｅ　ａ７　ｎｉｃｏｔｉｎｉｃ　ｒｅｃｅｐｔｏｒ　ｌｉｇａｎｄ　ｂｉｎｄｉｎｇ　ｄｏｍａｉｎ' Ｂｉｏｐｈｙｓｉｃａｌ　Ｊｏｕｒｎａｌ８８（４）, 2005, ２５６４-２５７６
JPN7016000328; Ｍ．　Ｐｏｈａｎｋａ: 'Ａｌｐｈａ７　ｎｉｃｏｔｉｎｉｃ　ａｃｅｔｙｌｃｈｏｌｉｎｅ　ｒｅｃｅｐｔｏｒ　ｉｓ　ａ　ｔａｒｇｅｔ　ｉｎ　ｐｈａｒｍａｃｏｌｏｇｙ　ａｎｄ　ｔｏｘｉｃｏｌｏｇｙ' Ｉｎｔｅｒｎａｔｉｏｎａｌ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｏｌｅｃｕｌａｒ　Ｓｃｉｅｎｃｅｓ１３, 2012, ２２１９-２２３８
JPN7016000325; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20120228
JPN7016000326; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110911
JPN6016005290; Ｙ．　Ｐｅｎｇ　ｅｔ　ａｌ: 'Ｄｉｓｃｏｖｅｒｙ　ｏｆ　ｎｏｖｅｌ　ａ７　ｎｉｃｏｔｉｎｉｃ　ｒｅｃｅｐｔｏｒ　ａｎｔａｇｏｎｉｓｔｓ' Ｂｉｏｏｒｇａｎｉｃ　ａｎｄ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ２０, 2010, ４８２５-４８３０
JPN6016005291; Ｒｏｄｒｉｇｕｅｚ　Ｌｏａｉｚａ，　Ｐｉｌａｒ；　Ｌｏｅｂｅｒ，　Ｓｔｅｆａｎ；　Ｈｕｅｂｎｅｒ，　Ｈａｒａｌｄ；　Ｇｍｅｉｎｅｒ，　Ｐｅｔｅｒ: 'Ｃｌｉｃｋ　Ｃｈｅｍｉｓｔｒｙ　ｏｎ　Ｓｏｌｉｄ　Ｐｈａｓｅ：　Ｐａｒａｌｌｅｌ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　Ｎ-Ｂｅｎｚｙｌｔｒｉａｚｏｌｅ　Ｃａｒｂｏｘａｍｉｄｅｓ　ａｓ　Ｓｕｐｅｒ-Ｐｏｔｅｎｔ' Ｊｏｕｒｎａｌ　ｏｆ　Ｃｏｍｂｉｎａｔｏｒｉａｌ　Ｃｈｅｍｉｓｔｒｙ８（２）, 2006, ２５２-２６１
JPN7016000298; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110529
JPN7016000299; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110524
JPN7016000300; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110518
JPN7016000301; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110505
JPN7016000302; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110505
JPN7016000303; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110505
JPN7016000304; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110503
JPN7016000305; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110502
JPN7016000306; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110429
JPN7016000307; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110413
JPN7016000308; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110412
JPN7016000309; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110410
JPN7016000310; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110410
JPN7016000311; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110410
JPN7016000312; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110410
JPN7016000313; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110128
JPN7016000314; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20100917
JPN7016000315; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20100325
JPN7016000316; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20100222
JPN7016000317; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20100222
JPN7016000318; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20090730
JPN7016000319; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20090415
JPN7016000320; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20081102
JPN7016000321; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20080926
JPN7016000322; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20080601
JPN7016000323; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20080313
JPN7016000324; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20071026
JPN7016000327; Ｒ．　Ｈ．　Ｈｅｎｃｈｍａｎ　ｅｔ　ａｌ: 'Ｌｉｇａｎｄ-ｉｎｄｕｃｅｄ　ｃｏｎｆｏｒｍａｔｉｏｎａｌ　ｃｈａｎｇｅ　ｉｎ　ｔｈｅ　ａ７　ｎｉｃｏｔｉｎｉｃ　ｒｅｃｅｐｔｏｒ　ｌｉｇａｎｄ　ｂｉｎｄｉｎｇ　ｄｏｍａｉｎ' Ｂｉｏｐｈｙｓｉｃａｌ　Ｊｏｕｒｎａｌ８８（４）, 2005, ２５６４-２５７６
JPN7016000328; Ｍ．　Ｐｏｈａｎｋａ: 'Ａｌｐｈａ７　ｎｉｃｏｔｉｎｉｃ　ａｃｅｔｙｌｃｈｏｌｉｎｅ　ｒｅｃｅｐｔｏｒ　ｉｓ　ａ　ｔａｒｇｅｔ　ｉｎ　ｐｈａｒｍａｃｏｌｏｇｙ　ａｎｄ　ｔｏｘｉｃｏｌｏｇｙ' Ｉｎｔｅｒｎａｔｉｏｎａｌ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｏｌｅｃｕｌａｒ　Ｓｃｉｅｎｃｅｓ１３, 2012, ２２１９-２２３８
JPN7016000325; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20120228
JPN7016000326; ＲＥＧＩＳＴＲＹ　［ＳＴＮ　ｏｎｌｉｎｅ］ , 20110911

Attorney, Agent or Firm:

Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Satoshi Hashimoto

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