Title:
腎髄質外層カリウムチャンネルの阻害薬
Document Type and Number:
Japanese Patent JP2014521751
Kind Code:
A
Abstract:
The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Inventors:
Path ターナク, Alexander
A blizzard, Timothy
チヨバニ Anh, Harry
デ Jesus, lei ナルダ
Dean, フアー * Shahn
Dawn, シユウジー
グデ, a can deed
Kim, ドウーソプ
A turn, Haiphong
Walsh, Sean
Pio, Barbara
ジアーン, Jin Ron
A blizzard, Timothy
チヨバニ Anh, Harry
デ Jesus, lei ナルダ
Dean, フアー * Shahn
Dawn, シユウジー
グデ, a can deed
Kim, ドウーソプ
A turn, Haiphong
Walsh, Sean
Pio, Barbara
ジアーン, Jin Ron
Application Number:
JP2014526222A
Publication Date:
August 28, 2014
Filing Date:
August 16, 2012
Export Citation:
Assignee:
Merck sharp and dome corporation Merck Sharp & Dohme Corp.
International Classes:
C07D487/04; A61K31/4985; A61K31/5383; A61K31/542; A61K45/00; A61P1/00; A61P1/16; A61P3/10; A61P3/14; A61P7/02; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P25/00; A61P43/00; C07D498/04; C07D513/04
Attorney, Agent or Firm:
Iwase Yoshiwa
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Yoshinori Kanayama
Michiaki Tsubokura
Kazuteru Shigemori
Kenji Ando
Yasufumi Shiroyama