Title:
DETECTION METHOD AND KIT FOR PHOSPHOLIPID HYDROPEROXIDE-DEPENDENT CELL DEATH, PROTEIN AND NUCLEIC ACID, PHOSPHOLIPID HYDROPEROXIDE-DEPENDENT CELL DEATH INHIBITOR, AND PREVENTIVE OR THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH PHOSPHOLIPID HYDROPEROXIDE-DEPENDENT CELL DEATH
Document Type and Number:
Japanese Patent JP2018121637
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a detection method and kit for phospholipid hydroperoxide-dependent cell death, a protein and nucleic acid, a phospholipid hydroperoxide-dependent cell death inhibitor, and a preventive or therapeutic agent for diseases by clarifying a factor involved in a cell death pathway caused by PHGPx depletion.SOLUTION: The invention provides a detection method for phospholipid hydroperoxide-dependent cell death having a step of detecting the production of phospholipid hydroperoxide and the activation of C87436 in a cell sample.SELECTED DRAWING: Figure 27
Inventors:
IMAI HIROTAKA
Application Number:
JP2018042356A
Publication Date:
August 09, 2018
Filing Date:
March 08, 2018
Export Citation:
Assignee:
KITASATO INST
International Classes:
C12N15/12; A61K31/7088; A61K31/7105; A61K31/713; A61K45/00; A61P9/04; C07K14/47; C12N15/113; C12Q1/6883; G01N33/50; G01N33/53
Other References:
MUS MUSCULUS EXPRESSED SEQUENCE C87436, MRNA (CDNA CLONE MGC:36408 IMAGE:5321669), COMPLETE CDS, JPN6019007175
オレオサイエンス, 2011, VOL.11, NO.11, PP.431-439, JPN6017049621
FASEB JOURNAL, 2011, VOL.25, PP.2135-2144, JPN6017049624
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, VOL.277, NO.51, PP.49927-49934, JPN6017049626
オレオサイエンス, 2011, VOL.11, NO.11, PP.431-439, JPN6017049621
FASEB JOURNAL, 2011, VOL.25, PP.2135-2144, JPN6017049624
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, VOL.277, NO.51, PP.49927-49934, JPN6017049626
Attorney, Agent or Firm:
Sumio Tanai
Masato Iida
Masato Iida