Title:
ATX MODULATING AGENTS
Document Type and Number:
Japanese Patent JP2018135379
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide: bicyclic aryl compounds that can modulate the activity of the autotaxin (ATX) enzyme; compounds that are ATX inhibitors; methods of using the compounds in treatment of demyelination due to injury or disease; and methods of using the compounds for treating proliferative disorders such as cancer.SOLUTION: The compounds are represented by the formulas in the figure.SELECTED DRAWING: None
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Inventors:
KEVIN GUCKIAN
GNANASAMBANDAM KUMARAVEL
MA BIN
MI SHA
PENG HAIRUO
SHAO ZHAOHUI
SUN LIHONG
ARTHUR TAVERAS
WANG DEPING
XIN ZHILI
LEI ZHANG
GNANASAMBANDAM KUMARAVEL
MA BIN
MI SHA
PENG HAIRUO
SHAO ZHAOHUI
SUN LIHONG
ARTHUR TAVERAS
WANG DEPING
XIN ZHILI
LEI ZHANG
Application Number:
JP2018088836A
Publication Date:
August 30, 2018
Filing Date:
May 02, 2018
Export Citation:
Assignee:
BIOGEN MA INC
International Classes:
C07C229/48; A61K31/196; A61K31/439; A61K31/445; A61K31/472; A61K31/5375; A61K45/00; A61P11/00; A61P11/06; A61P19/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D211/34; C07D211/62; C07D217/22; C07D295/096; C07D401/06; C07D471/08
Domestic Patent References:
| JP2004510764A | 2004-04-08 | |||
| JP6391571B2 | 2018-09-19 | |||
| JP2005524679A | 2005-08-18 | |||
| JP2009535393A | 2009-10-01 | |||
| JP2007518824A | 2007-07-12 | |||
| JPH09124606A | 1997-05-13 | |||
| JP2009519908A | 2009-05-21 |
Foreign References:
| WO2011017561A1 | 2011-02-10 | |||
| WO2010093704A1 | 2010-08-19 | |||
| WO2006064757A1 | 2006-06-22 |
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Ichinomiya
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Ichinomiya