Title:
神経筋疾患、神経変性疾患、自己免疫疾患、発達疾患および／または代謝疾患の処置のための、脳由来神経栄養因子（ＢＤＮＦ）の誘導された発現
Document Type and Number:
Japanese Patent JP2018502898
Kind Code:
A
Abstract:
一実施形態では、本発明は、外傷性ＣＮＳ傷害、神経変性疾患、および／または自己免疫疾患、および／または発達障害、および／または代謝疾患を、ＢＤＮＦを増大させて疾患の進行を和らげるまたは症状の軽減をもたらすために、ＤＮＰを体重１ｋｇ当たり０．０１ｍｇ〜体重１ｋｇ当たり１０ｍｇ未満の用量範囲で投与することによって処置する方法を提供する。ＤＮＰを様々な用量にわたってマウスに毎日投与し、その後、脳におけるＢＤＮＦ発現に用量依存性かつ非線形の発現の増大が示された。
Inventors:
Alonso, Robert
Geisler, John Gerrard
Geisler, John Gerrard
Application Number:
JP2017539363A
Publication Date:
February 01, 2018
Filing Date:
January 21, 2016
Export Citation:
Assignee:
Mightcon Pharmaceuticals, Inc.
International Classes:
A61K31/06; A61P3/00; A61P3/10; A61P9/10; A61P17/02; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P29/00; A61P37/02; A61P43/00
Foreign References:
| US6664297B1 | 2003-12-16 |
Other References:
IUBMB LIFE, vol. 58, no. 4, JPN6019043007, 2006, pages 185 - 191, ISSN: 0004375987
RODRIGO F MADEIRO DA COSTA: "2,4-DINITROPHENOL BLOCKS NEURODEGENERATION AND PRESERVES SCIATIC NERVE FUNCTION AFTER TRAUMA", JOURNAL OF NEUROTRAUMA, vol. VOL:27, NR:5, JPN5017011225, May 2010 (2010-05-01), US, pages 829 - 841, ISSN: 0004375988
MAKOTO URUSHITANI: "N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED MITOCHONDRIAL CA2+ OVERLOAD IN ACUTE 以下備考", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 63, JPN5017011227, 2001, pages 377 - 387, ISSN: 0004547116
RODRIGO F MADEIRO DA COSTA: "2,4-DINITROPHENOL BLOCKS NEURODEGENERATION AND PRESERVES SCIATIC NERVE FUNCTION AFTER TRAUMA", JOURNAL OF NEUROTRAUMA, vol. VOL:27, NR:5, JPN5017011225, May 2010 (2010-05-01), US, pages 829 - 841, ISSN: 0004375988
MAKOTO URUSHITANI: "N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED MITOCHONDRIAL CA2+ OVERLOAD IN ACUTE 以下備考", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 63, JPN5017011227, 2001, pages 377 - 387, ISSN: 0004547116
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto