Title:
ANTI-TFPI ANTIBODY VARIANTS WITH DIFFERENTIAL BINDING ACROSS pH RANGE FOR IMPROVED PHARMACOKINETICS
Document Type and Number:
Japanese Patent JP2019069973
Kind Code:
A
Abstract:
To provide a therapeutic composition that comprises an isolated human monoclonal IgG antibody that binds specifically to human tissue factor pathway inhibitor (TFPI) and has an increased plasma half-life.SOLUTION: An antibody comprises at least one histidine substitution in a CDR region in either a human heavy chain or a human light chain, and binds to TFPI at pH 7.4 with at least two fold higher affinity than at pH 6.0.SELECTED DRAWING: Figure 2
Inventors:
WANG ZHUOZHI
MURPHY E JOHN
RUTH WINTER
MURPHY E JOHN
RUTH WINTER
Application Number:
JP2018235059A
Publication Date:
May 09, 2019
Filing Date:
December 17, 2018
Export Citation:
Assignee:
BAYER HEALTHCARE LLC
International Classes:
A61K39/395; A61P7/04; C07K16/18
Domestic Patent References:
| JP2012116837A | 2012-06-21 |
Foreign References:
| WO2011109452A1 | 2011-09-09 |
Other References:
NATURE BIOTECHNOLOGY, vol. 28, no. 11, JPN6017039782, 2010, pages 1203 - 1208, ISSN: 0004142316
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Takuya Gomibuchi
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Takuya Gomibuchi
Yoshikazu Iwase
Yasufumi Shiroyama
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