Title:
GLUCAGON INHIBITOR, GLUCAGON INHIBITING COMPOSITION AND GLUCAGON INHIBITING FOOD COMPOSITION
Document Type and Number:
Japanese Patent JP2021105059
Kind Code:
A
Abstract:
To provide a novel pharmaceutical agent that acts to inhibit glucagon.SOLUTION: The inventors discovered that after leptin receptor deficient model mice were given free access to feed containing arctigenin for 9 weeks, the blood glucagon concentration measured in the mice was lower in comparison to the blood glucagon concentration of a control group. Furthermore, it was discovered that in the mice administered with arctigenin, the expression level of downstream genes promoted by glucagon including FOXO1, PGC1α, PEPCK, AND G6Pase was also lower than a control group. The present invention provides a glucagon inhibitor containing arctigenin and/or arctiin as active ingredients.SELECTED DRAWING: Figure 1
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Inventors:
INAMASU SATOSHI
WATABE SHIMPEI
WATANABE MITSUHIRO
TAKASHINA YOKO
WATABE SHIMPEI
WATANABE MITSUHIRO
TAKASHINA YOKO
Application Number:
JP2021070134A
Publication Date:
July 26, 2021
Filing Date:
April 19, 2021
Export Citation:
Assignee:
KRACIE HOLDINGS LTD
International Classes:
A61K31/7048; A23L33/105; A61K31/365; A61K36/28; A61K36/634; A61P3/08; A61P35/00
Domestic Patent References:
| JP2008297209A | 2008-12-11 | |||
| JP2010503712A | 2010-02-04 |
Other References:
DIABETOLOGIA, vol. 55, JPN6020043312, 2012, pages 1469 - 1481, ISSN: 0004771980
ACTA PHARMACOLOGICA SINICA, vol. 35, JPN6020043313, 2014, pages 1274 - 1284, ISSN: 0004771981
ACTA PHARMACOLOGICA SINICA, vol. 35, JPN6020043313, 2014, pages 1274 - 1284, ISSN: 0004771981
Attorney, Agent or Firm:
Rei Aihara
Moriwaki Rio
Moriwaki Rio