Title:
プレグネノロンの鼻腔内送達のための組成物および方法
Document Type and Number:
Japanese Patent JP2021522170
Kind Code:
A
Abstract:
本発明は、アセチルコリン活性の低下に関連する疾患または障害を治療するために、特定の脳領域における神経伝達物質アセチルコリンの活性を増加させる方法に関する。特に、これらの方法は、一方の鼻孔のみへのプレグネノロンの鼻腔内投与に関連し、この鼻孔に対応する扁桃体でのみアセチルコリン活性を増加させ、したがってアセチルコリン活性の同側の増加を提供する。【選択図】図１
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Inventors:
Mattern Claudia
Application Number:
JP2020557201A
Publication Date:
August 30, 2021
Filing Date:
April 16, 2019
Export Citation:
Assignee:
MPE Pepharma Akchengezel Shaft
International Classes:
A61K31/573; A61K9/06; A61P9/00; A61P17/02; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/00
Foreign References:
| WO2017208209A1 | 2017-12-07 | |||
| WO2010077292A1 | 2010-07-08 |
Other References:
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C. ERIKSSON ET AL.: "Transfer of Some Carboxylic Acids in the Olfactory System Following Intranasal Administration", JOUNAL OF DRUG TARGETING, vol. 7(2), JPN7023001225, 1999, pages 131 - 142, ISSN: 0005024806
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N. DUCHARM ＥＴ AL.: "Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intra", EUROPIAN JOURNAL OF PHARMACOLOGY, vol. 641(2-3), JPN7023001223, 2010, pages 128 - 134, ISSN: 0005024804
L. HASTINGS AND J. E. EVANS: "Olfactory Primary Neurons as a Route of Entry for Toxic Agents into the CNS", NEROTOXICOLOGY, vol. 12(4), JPN7023001226, 1991, pages 707 - 714, ISSN: 0005024805
C. ERIKSSON ET AL.: "Transfer of Some Carboxylic Acids in the Olfactory System Following Intranasal Administration", JOUNAL OF DRUG TARGETING, vol. 7(2), JPN7023001225, 1999, pages 131 - 142, ISSN: 0005024806
M. PALLARES ET AL.: "The neurosteroid pregnenolone sulfate infused into the nucleus basalis increases both acethylcholine", NEUROSCIENCE, vol. 87(3), JPN7023001224, 1998, pages 551 - 558, ISSN: 0005024807
C. E. MARX ET AL.: "PregnenoIone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical ev", NEUROSCIENCE, vol. 191, JPN7023001222, 2011, pages 78 - 90, XP028279499, ISSN: 0005024808, DOI: 10.1016/j.neuroscience.2011.06.076
Attorney, Agent or Firm:
Shinichiro Tanaka
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Kobayashi Machiko
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Kobayashi Machiko