Title:
【発明の名称】ロイコトリエン拮抗剤
Document Type and Number:
Japanese Patent JP2677382
Kind Code:
B2
Abstract:
Compounds of formula: in which, inter alia q is 0 to 2, R1 is (L)a-(CH2)b-(T)c-B wherein a and c are 0 or 1, b is 3 to 14, L and T are independently O, S or CH2; B is C1-4 alkyl, ethynyl, CF3, isopropenyl, furanyl, thienyl, furanyl, cyclohexyl or optionally substituted phenyl; R2 and A are H, CF3, C1-4 alkyl, C1-4 alkoxy, halogen, OH, NO2 or NH2 or R1 and A are H and R2 is (L)a-(CH2)b-(T)c as above; y is COR3 or (CHX)n(CH2)pZ wherein R3 is OH, NH2, aryloxy or alkoxy, n is 0 or 1, p is 0, 1 and 2; X is H, OH, alkyl, alkoxy or F, Z is COR3 or tetrazolyl; R is (CR4R5)mW, m is 0 to 6, R4 and R5 are alkyl and W is an optionally substituted heteroaryl group; intermediates and processes for their preparation and their use in therapy as leukotriene antagonists.
Inventors:
John Gerard Gleason
Ralph Floyd Hall
Irene Nijore Eugenescus
Ralph Floyd Hall
Irene Nijore Eugenescus
Application Number:
JP14794088A
Publication Date:
November 17, 1997
Filing Date:
June 15, 1988
Export Citation:
Assignee:
SmithKline Beckman Corporation
International Classes:
A61K31/34; A61K31/341; A61K31/41; A61K31/425; A61K31/426; A61K31/433; A61P11/00; A61P37/06; C07D249/08; A61P37/08; A61P43/00; C07D207/333; C07D233/64; C07D233/84; C07D249/04; C07D249/12; C07D257/04; C07D263/32; C07D263/46; C07D277/20; C07D277/36; C07D277/56; C07D285/12; C07D285/125; C07D307/68; C07D333/18; (IPC1-7): C07D257/04; C07D277/36; C07D277/56; C07D285/12; C07D307/68
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)