Title:
【発明の名称】抗腫瘍性の6‐スルフェンアミド、6‐スルフィンアミドおよび6‐スルホンアミドプリン類、プリンヌクレオシド類、プリンヌクレオチド類、並びに関連化合物類
Document Type and Number:
Japanese Patent JP2698460
Kind Code:
B2
Abstract:
6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: wherein Z is H or -NH2; X is -S-NH2, T is C-H, G is N and Q is N; or T is C-H, G is N and Q is C-H; or T is N, G is N and Q is C-H; or T is C-H, G is C-H and Q is N; Y is H or an alpha -pentofuranose or beta -pentofuranose of the formula: wherein R1 and R2 independently are H, OH, -O-acyl or or together R1 and R2 are and R3 and R4 are H or one of R3 or R4 is OH and the other is H; provided that when Y is H, Z is -NH2; and acceptable salt thereof are prepared and are useful as antitumor agents or they are intermediates for compounds which are antitumor agents. The compounds are used to treat an affected warm blooded host by serving as the active ingredients of suitable pharmaceutical compositions.
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Inventors:
Robbins, Roland Kennis
Lebanker, Ganapasi Rama Krishma
Hannah, Naem Botoros
Lebanker, Ganapasi Rama Krishma
Hannah, Naem Botoros
Application Number:
JP50064688A
Publication Date:
January 19, 1998
Filing Date:
December 13, 1988
Export Citation:
Assignee:
Nucleic Acid Research Institute
International Classes:
A61K31/435; A61K31/505; A61K31/52; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61P35/00; C07D471/04; C07D473/38; C07D487/04; C07H19/06; C07H19/14; C07D473/24; C07H19/16; C07H19/20; C07H19/213; (IPC1-7): C07D471/04; A61K31/435; A61K31/505; A61K31/52; A61K31/70; C07D471/04; C07D473/24; C07D473/38; C07D487/04; C07H19/16; C07H19/20; C07H19/213
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)