Title:
【発明の名称】海洋生物を原料とした代用皮膚
Document Type and Number:
Japanese Patent JP2731833
Kind Code:
B2
Abstract:
There is provided a skin substitute that can suitably be used for covering the surface of a damaged skin area which is typically a wound produced by a traumatic local loss of the skin of the human body as a result of a burn or some other cause of damage. It is a skin substitute of a laminate comprising a squid chitin sheet and a fish skin collagen coat layer, which may be a salmon skin collagen coat layer. Such a skin substitute effectively exploits the suppleness and the effect of proving an environment for encouraging the production of lysozyme and defending the wound of squid chitin and, at the same time, compensate the disadvan- tage of poor adhesion of fibroblast cells that operate for curing the wound. Additionally, the fibroblast cells adhering to a laminate of a squid chitin sheet and a fish skin collagen coat layer showed a normal cell proliferation curve without any delayed initial rising phase to prove the former more satisfactory that cannot be expected from a laminate comprising a calf skin collagen coat layer. Finally, a DNA labeling index substantially equal to that of fibroblast cells of normal human skin was observed.
Inventors:
TAKAI MITSUO
SHIMIZU JUICHI
SHIMIZU JOSUKE
YAMAZAKI KUNIO
KUMABAYASHI YOSHITERU
SHIMIZU HIDEKI
YAMADA KUNISHIGE
SHIMIZU JUICHI
SHIMIZU JOSUKE
YAMAZAKI KUNIO
KUMABAYASHI YOSHITERU
SHIMIZU HIDEKI
YAMADA KUNISHIGE
Application Number:
JP18217295A
Publication Date:
March 25, 1998
Filing Date:
June 26, 1995
Export Citation:
Assignee:
DAIDO HOKUSAN KK
HOTSUKAIDO
HOTSUKAIDO
International Classes:
A61F2/10; A61K35/60; A61L27/00; A61L15/28; A61L15/32; A61L15/40; A61L27/60; (IPC1-7): A61F2/10; A61L27/00
Domestic Patent References:
| JP5285211A | ||||
| JP4108444A | ||||
| JP341131A |
Attorney, Agent or Firm:
Yoshio Saito