Title:
【発明の名称】組換ヒト肝実質細胞増殖因子及びその製造方法
Document Type and Number:
Japanese Patent JP2777678
Kind Code:
B2
Abstract:
PURPOSE:To obtain a new DNA useful for producing a polypeptide having activities similar to those of human HGF. CONSTITUTION:A DNA containing a base sequence encoding a human leukocyte- derived hepatocyte growth factor, for example, having a restriction map of the figure. A cDNA containing a base sequence encoding rat HGF polypeptide is obtained from a cDNA library prepared by a rat liver mRNA by an olionulectide probe synthesized based on an amino acid sequence of rat platelet- derived HGF. A cDNA containing a base sequence encoding a human HGF polypeptide is obtained from a cDNA library prepared from human liver mRNA by using the rat-derived cDNA as a probe.
Inventors:
NAKAMURA TOSHIICHI
HAGYA MICHIO
SEKI TATSUYA
SHIMONISHI MANABU
SHIMIZU SHIN
INOHARA IZUMI
SAKAGUCHI MARIKO
ASAMI OSAMU
HAGYA MICHIO
SEKI TATSUYA
SHIMONISHI MANABU
SHIMIZU SHIN
INOHARA IZUMI
SAKAGUCHI MARIKO
ASAMI OSAMU
Application Number:
JP16348591A
Publication Date:
July 23, 1998
Filing Date:
June 06, 1991
Export Citation:
Assignee:
NAKAMURA TOSHIICHI
International Classes:
A61K38/00; A61K38/22; A61P1/16; A61P43/00; C07K1/20; C07K1/22; C07K14/00; C07K14/475; C07K14/52; C12N5/10; C12N15/09; C12N15/16; C12N15/85; C12P21/02; C12R1/91; (IPC1-7): C12N15/09; C12P21/02
Other References:
ＮＡＴＵＲＥ，１９８９年，第３４２巻，Ｐ．４４０−４４３
Attorney, Agent or Firm:
Hiromi Hirose