Title:
【発明の名称】抗D-免疫グロブリンGの濃縮物の製造方法、それを含む製薬的調剤
Document Type and Number:
Japanese Patent JP2926463
Kind Code:
B2
Abstract:
An anti-D immunoglobulin G product is prepared from plasma containing human anti-D IgG or a plasma fraction containing anti-D IgG by A) subjecting the plasma or plasma fraction at a pH in the range from 3.5 to 6.5 to an ion exchange chromatography using an adsorbent which has carboxymethyl groups as functional groups, with the anti-D IgG being bound to the adsorbent, B) washing the adsorbent with bound anti-D IgG using a washing solution, and subsequently eluting the anti-D IgG, and further C) treating the eluted anti-D IgG with a basic adsorbent with ion exchange properties in order to bind unwanted components, and finally concentrating the anti-D IgG. The non-infectious anti-D concentrate is obtained in good yield and has a specific activity of more than 0.5% anti-D IgG per gram of total IgG.
Inventors:
GERUHARUTO HODORAA
PEETAA RERUHI
MARUTEIN SHUTATSUKI
PEETAA RERUHI
MARUTEIN SHUTATSUKI
Application Number:
JP33701794A
Publication Date:
July 28, 1999
Filing Date:
December 27, 1994
Export Citation:
Assignee:
ROTOKUREETSUSHUTEIFUTSUNGU ZENTORARU LAB BURUTSUPENDEIENSHUTO ESU AARU KEI
International Classes:
A61K39/395; A61K9/08; A61K47/02; A61K47/18; A61K47/26; C07K1/18; C07K16/00; C07K16/06; C07K16/34; (IPC1-7): A61K39/395
Attorney, Agent or Firm:
Tadashi Hagino (3 outside)